Int J Sports Med 2014; 35(02): 172-177
DOI: 10.1055/s-0033-1347171
Genetics & Molecular Biology
© Georg Thieme Verlag KG Stuttgart · New York

ACTN3 R577X Genotype is Associated with Sprinting in Elite Japanese Athletes

E. Mikami
1  Graduate School of Sport Sciences, Waseda University, Tokorozawa-city, Japan
,
N. Fuku
2  Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
,
H. Murakami
3  Department of Health Promotion and Exercise Program, National Institute of Health and Nutrition, Tokyo, Japan
,
H. Tsuchie
4  Faculty of Business Administration, Josai University, Saitama, Japan
,
H. Takahashi
5  Department of Sports Science, Japan Institute of Sports Sciences, Tokyo, Japan
,
N. Ohiwa
5  Department of Sports Science, Japan Institute of Sports Sciences, Tokyo, Japan
,
H. Tanaka
6  Faculty of Sport and Health Science, Fukuoka University, Fukuoka, Japan
,
Y. P. Pitsiladis
7  Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom
,
M. Higuchi
8  Faculty of Sport Sciences, Waseda University, Saitama, Japan
,
M. Miyachi
3  Department of Health Promotion and Exercise Program, National Institute of Health and Nutrition, Tokyo, Japan
,
T. Kawahara
9  Department of Sports Medicine, Japan Institute of Sports Sciences, Tokyo, Japan
,
M. Tanaka
2  Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
› Author Affiliations
Further Information

Publication History



accepted after revision 18 April 2013

Publication Date:
18 July 2013 (eFirst)

Abstract

The ACTN3 R577X genotype has been found to associate with sprint/power phenotypes in all elite athlete cohorts investigated. This association has not been extensively studied in elite Asian athletes. The present study was undertaken to investigate the association between the ACTN3 R577X genotype and elite Japanese track and field athlete status. 299 elite Japanese track and field athletes (134 sprint/power athletes; 165 endurance/middle-power athletes) and 649 Japanese controls were genotyped for the ACTN3 R577X polymorphism. All athletes were of national or international level. Sprint/power athletes showed a higher frequency of RR+RX genotype than controls (111/134 [82.8%] vs. 478/649 [73.7%], P=0.025 under the R-dominant model), while there was no significant difference between endurance/middle-power athletes and controls (126/165 [76.4%] vs. 478/649 [73.7%], P=0.48 under the R-dominant model). Sprinters with the RR+RX genotype had significantly faster personal best times for the 100 m than those with XX genotype (10.42±0.05 s vs. 10.64±0.09 s, P=0.042); no such association was found in the 400 m sprinters (47.02±0.36 s vs. 47.56±0.99 s, P=0.62). ACTN3 R577X genotype is associated with sprint/power performance in elite Japanese track and field athletes, especially short sprint performance.