Abstract
Aim The aim of this study was to evaluate the relationship between clinical and cranial
magnetic resonance imaging findings in patients with corpus callosum (CC) abnormalities.
Patients and Methods Between September 2010 and March 2012, patients with developmental CC abnormalities
were included in the study. CC abnormalities were classified as total agenesis, partial
agenesis, and callosal hypoplasia. Regarding the groups, the association between radiological
abnormalities and clinical findings were evaluated.
Results A total of 62 patients (32 females [51.6%] and 30 males [48.4%]) with a mean age
of 18.0 ± 32.1 months were enrolled in the study. Of them, 20 patients (32.3%) had
total agenesis, 9 patients (14.5%) had partial agenesis, and 33 (53.2%) patients had
hypoplasia of the CC. Thirty-five cases (56.7%) had abnormal physical examination,
47 cases (75.8%) had abnormal neurological examination, and 42 cases (67.7%) had psychomotor
retardation. There were no significant differences between groups regarding physical
examination, psychomotor retardation, seizures, or microcephaly. Seizures, psychomotor
retardation, and neurological abnormalities were significantly more frequent in patients
with associated other radiological abnormalities. Posterior segment of the CC was
significantly thinner in patients with psychomotor retardation and the anterior part
of the CC thinner in patients with abnormal physical examination. Patients with total
agenesis were more prone to seizures at an early age than patients with partial agenesis
or hypoplasia.
Conclusion The neurological prognosis of patients with CC abnormalities is poorer in patients
with an associated neuroradiological abnormality. Early development of seizures may
be observed in cases with total agenesis of the CC.
Keywords
corpus callosum thickness - corpus callosum agenesis - magnetic resonance imaging
- clinical findings
