Planta Med 2013; 79(17): 1589-1598
DOI: 10.1055/s-0033-1351024
Reviews
Georg Thieme Verlag KG Stuttgart · New York

Daphniphyllum Alkaloids: Recent Findings on Chemistry and Pharmacology

Haifeng Wu
1   Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
,
Xiaopo Zhang
1   Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
,
Lisheng Ding
2   Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China
,
Shilin Chen
1   Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
3   Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
,
Junshan Yang
1   Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
,
Xudong Xu
1   Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
› Author Affiliations
Further Information

Publication History

received 07 April 2013
revised 22 June 2013

accepted 16 September 2013

Publication Date:
08 November 2013 (online)

Abstract

The unique polycyclic fused ring systems of Daphniphyllum alkaloids, along with their extensive bioactivities, make this family of alkaloids especially attractive targets for total synthesis and biogenetic studies. Successive discoveries of new alkaloids with unprecedented skeletons have made a great contribution to structural diversities of alkaloids elaborated by plants of the genus Daphniphyllum. By the end of 2008, more than 200 alkaloids belonging to 14 different skeletal types have been isolated from different parts of plants of thirteen Daphniphyllum species. These alkaloids show cytotoxic, antioxidant, vasorelaxant, and antiplatelet activating factor effects. The plausible biosynthetic pathways for Daphniphyllum alkaloids have been proposed and biomimetic total syntheses of some alkaloids completed. To provide an update of the previous reviews published in 2009, new structures, synthesis, and bioactivity of Daphniphyllum alkaloids reported in recent years are presented in this article. In the meantime, an additional 54 novel alkaloids have been isolated and identified. Among them, some possess unprecedented frameworks. Several inspired organic syntheses were completed.

 
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