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Planta Med 2013; 79(18): 1730-1735
DOI: 10.1055/s-0033-1351100
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Bioactive Benzofuran Neolignans from Aristolochia fordiana

Zhong-bo Zhou
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, PR China
,
Jian-guang Luo
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, PR China
,
Ke Pan
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, PR China
,
Si-ming Shan
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, PR China
,
Wei Zhang
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, PR China
,
Ling-yi Kong
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, PR China
› Author Affiliations
Further Information

Publication History

received 31 July 2013
revised 01 October 2013

accepted 24 October 2013

Publication Date:
28 November 2013 (online)

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Abstract

Six new benzofuran neolignans (1–6) were isolated from the EtOAc-soluble fraction of the aerial part of Aristolochia fordiana, together with twelve known analogues (7–18). The structures of the isolated compounds were elucidated by spectroscopic methods. All isolates were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccaride-activated RAW264.7 macrophages and for their cytotoxic activities on three human cancer cell lines. Compound 2 showed significant nitric oxide production inhibitory activity with an IC50 value of 10.00 µM, while compound 16 exhibited cytotoxic activity with an IC50 value of 11.9 µM against MG-63 and compound 18 of 9.15 µM against HepG2 cell lines, respectively.

Key words

neolignans - Aristolochiaceae - Aristolochia fordiana - nitric oxide - cytotoxicity

Supporting Information

 

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