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DOI: 10.1055/s-0033-1352131
Isolation of some chemical constituents from licorice and their evaluation as anticancer and antiviral agents
Ten compounds were isolated from the methanol extract of Glycyrrhiza glabra L., they were identified as 2-O-β-D-Xylopyranoside,(3- methoxy phenyl) 4'-methoxy, 3',5' dihydroxybenzofuran [1], ergosta-7,22-dien-3β,5α,6β,9α-tetraol [2], 5,2',4'-trihydroxy, 8,3'-dimethoxy 4',5' hydroxyisopropyldihydrofuran flavanol [3], isolicoflavanol [4], 7-O-β-D-xylopyranosyl (1→4) β-D-glucopyranosyl 6-O-isobutyl isoflavone [5], licorice saponin L 3 [6], Lipinifolin [7], licochalcone B [8] isoliquirtin [9] and isoliquiritigenin [10]. Eight compounds were evaluated for anticancer and antiviral activities, they were tested on three cytokines of the human ascites fluid, TNF-alpha, Interferons-gamma and NO. All tested compounds showed significant curative effect compared to control. Compound [8] showed significant decrease compared with control (p < 0.01) in both HCV and malignant HCV cases in the three cytokines of the human ascites fluid after 24 and 48 hours followed by compound [3].