Planta Med 2013; 79 - PI73
DOI: 10.1055/s-0033-1352162

Secondary metabolites from Scutellaria velenovskyi Rech. f.

M Matsa 1, C Gousiadou 1, H Bardakcı 2, H Kırmızıbekmez 2, H Skaltsa 1
  • 1Department of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, 157 71, Athens, Greece
  • 2Department of Pharmacognosy, Faculty of Pharmacy, Yeditepe University, 34755 Kayisdagi, Istanbul, Turkey

The aim of this study was to determine the chemical profile of Scutellaria velenovskyi (Lamiaceae), which is endemic to the Balkan Peninsula and Turkey [1]. It is taxonomically classified to the S. albida group. The plant material was collected from Karabük, Turkey. The methanol extract of the aerial parts was fractionated using RP18-MPLC, flash chromatography and semi-prep RP18-HPLC. Three iridoids, catalpol, albidoside, macfadienoside, four phenylethanoid glycosides, verbascoside, martynoside, leucoseptoside A, glucopyranosyl-(1 – 6)-martynoside, one phenolic derivative, p-(E)-coumaroyl glucopyranose and three flavonoids, scutellarein 7-O-β-glucuronopyranoside, hispidulin 7-O-β-glucuronopyranoside and eriodictyol were isolated and identified. The structures of the isolates were elucidated by spectroscopic methods including 1D- & 2D-NMR, UV-Vis. The chemical profile of this taxon is quite similar to that of previously investigated species belonging to the S. albida group, i.e. S. albida subsp. albida [2, 3], S. albida subsp. colchica [4] and S. goulimii [5].

References:

[1] Bothmer, R. (1985) Nord. J. Bot. 5: 421 – 439.

[2] Gousiadou, C. et al. (2007) Phytochemistry, 68: 1799 – 1804.

[3] Gousiadou, C. et al. (2012)J. Enzyme. Inhib. Med. Chem. doi:10.3109/14756366.

[4] Çalis, I. et al. (1993) Phytochemistry 32: 1213 – 1217.

[5] Gousiadou, C. (2012) BSE. 43:139 – 141.

Acknowledgements: This research has been co-financed by GSRT (grant 84889) and TUBITAK (SBAG-109S480).