New Bisnorsesquiterpenes, sesquiterpene lactone and neolignan glycoside from Maytenus senegalensis leaves: structures and cytotoxic activity

Chemical investigation of the methanol leaf extract of Maytenus senegalensis led to the isolation of 16 compounds, including the new maysecyclononeone A, (6S, 9S) 9,10-dihydroxy-4,7Z-megastigmadien-3-one, mayselignoside A and maysefuropyranone A. In addition the following known compounds, viz. (+) lyoniresinol, (-) isolariciresinol, dihydrodehydrodiconiferyl alcohol, (-) epicathechin, (+) gallocatechin, (-) epigallocatechin, procyanidin B-2, 2,3-Dihydrokaempferol 3-O-β-D-glucopyranoside, quercetin 3-O-β-D-glucopyranoside, kaempferol 3-O-β-D- xylopyranoside, 3,5-dimethylgallate and benzoyl maleic acid were also isolated. The structures of the compounds were deduced by a combination of 1 D and 2 D NMR spectroscopy and high resolution mass spectrometry. All compounds were tested for cytotoxicity against mouse lymphoma cell line (L5178Y). Of the 16 compounds only (-) epigallocatechin showed high cytotoxicity and completely inhibited cell growth at the dose of 10 µg/mL.