Drug Research, Inhaltsverzeichnis Drug Res (Stuttg) 2014; 64(S 01): S22-S23DOI: 10.1055/s-0033-1358037 Symposium der Paul-Martini-Stiftung Georg Thieme Verlag KG Stuttgart · New YorkWirt-orientierte Therapien bei Influenza – Was heißt das? Authors Institutsangaben S. Ludwig Institut für Molekulare Virologie (IMV), Zentrum für Molekularbiologie der Entzündung (ZMBE), Westfälische-Wilhelms Universität Münster Artikel empfehlen Abstract Volltext Referenzen Literatur 1 Droebner K, Pleschka S, Ludwig S et al. Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1 v and highly pathogenic avian influenza virus in vitro and in vivo. Antiviral Res 2011; 92: 195-203 2 Ehrhardt C, Ruckle A, Hrincius ER et al. The NF-kappaB inhibitor SC75741 efficiently blocks influenza virus propagation and confers a high barrier for development of viral resistance. Cell Microbiol 2013; 15: 1198-1211 3 Haasbach E, Hartmayer C, Planz O. Combination of MEK inhibitors and oseltamivir leads to synergistic antiviral effects after influenza A virus infection in vitro. Antiviral Res 2013; 98: 319-324 4 Haasbach E, Reiling SJ, Ehrhardt C et al. The NF-kappaB inhibitor SC75741 protects mice against highly pathogenic avian influenza A virus. Antiviral Res 2013; 99: 336-344 5 Ludwig S, Wolff T, Ehrhardt C et al. MEK inhibition impairs influenza B virus propagation without emergence of resistant variants. FEBS Lett 2004; 561: 37-43 6 Ludwig S, Zell R, Schwemmle M et al. Influenza, a One Health paradigm – novel therapeutic strategies to fight a zoonotic pathogen with pandemic potential (2014). Available online 7 Ludwig S. Will omics help to cure the flu?. Trends Microbiol 2014; 22: 232-233 8 Marjuki H, Alam MI, Ehrhardt C et al. Membrane accumulation of influenza A virus hemagglutinin triggers nuclear export of the viral genome via protein kinase Calpha-mediated activation of ERK signaling. J Biol Chem 2006; 281: 16707-16715 9 Mazur I, Wurzer WJ, Ehrhardt C et al. Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-kappaB-inhibiting activity. Cell Microbiol 2007; 9: 1683-1694 10 Pinto R, Herold S, Cakarova L et al. Inhibition of influenza virus-induced NF-kappaB and Raf/MEK/ERK activation can reduce both virus titers and cytokine expression simultaneously in vitro and in vivo. Antiviral Res 2011; 92: 45-56 11 Planz O. Development of cellular signaling pathway inhibitors as new antivirals against influenza. Antiviral Res 2013; 98: 457-468 12 Pleschka S, Wolff T, Ehrhardt C. Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade. Nat Cell Biol 2001; 3: 301-305 13 Wurzer WJ, Ehrhardt C, Pleschka S et al. NF-kappaB-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas/FasL is crucial for efficient influenza virus propagation. J Biol Chem 2004; 279: 30931-30937 14 Wurzer WJ, Planz O, Ehrhardt C et al. Caspase 3 activation is essential for efficient influenza virus propagation. EMBO J 2003; 22: 2717-2728