Neuropediatrics 2013; 44(06): 324-329
DOI: 10.1055/s-0033-1358604
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Update on Pediatric Opsoclonus Myoclonus Syndrome

Barbara Hero
1   Department of Pediatric Oncology, Children's Hospital, University of Cologne, Köln, Germany
,
Gudrun Schleiermacher
2   Institut Curie, Paris, France
› Author Affiliations
Further Information

Publication History

17 July 2013

05 September 2013

Publication Date:
07 November 2013 (online)

Abstract

Opsoclonus myoclonus syndrome (dancing eye syndrome) is a rare paraneoplastic syndrome characterized by opsoclonus, myoclonus, and ataxia, usually accompanied by behavioral abnormalities. In adults, opsoclonus myoclonus syndrome has been reported in association with different types of cancer; whereas in children, the syndrome may be associated with neuroblastic tumors. Although a direct proof is lacking, the syndrome is assumed to be of autoimmune origin. The treatment is corticosteroid based with the addition of other immunosuppressive or immunomodulating drugs if intensification seems necessary. Because of the rarity of the disease, international collaborations as well on research as on therapeutic strategies are urgently needed. A European consortium just started a trial for this rare condition.

 
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