Synthesis and Characterization of Some Substituted 3, 4-dihydronaphthalene Derivatives through Different Enaminones as Potent Cytotoxic Agents

M. E. Haiba; E. S. Al-Abdullah; M. M. Edrees; N. M. Khalifa

doi:10.1055/s-0034-1368721

Drug Research, Table of Contents

Drug Res (Stuttg) 2015; 65(1): 9-17
DOI: 10.1055/s-0034-1368721

Original Article

Synthesis and Characterization of Some Substituted 3, 4-dihydronaphthalene Derivatives through Different Enaminones as Potent Cytotoxic Agents

Authors

M. E. Haiba

¹Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia

²Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Center, Cairo, Egypt
E. S. Al-Abdullah

¹Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia
M. M. Edrees

³Department of Organic Chemistry, National Organization for Drug Control and Research (NODCAR), Giza, Egypt

⁴Department of Chemistry, Faculty of Science, King Khalid University, Abha, Saudi Arabia
N. M. Khalifa

²Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Center, Cairo, Egypt

⁵Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

Abstract

A new series of novel substituted 3,4-dihydronaphthalene incorporated to benzo[h]quinoline, benzo[g]indazole, thiazolidin-4-one, pyrazolo[3,4-d]thiazol and thiazolo[4,5-b]pyridine ring systems were synthesized and evaluated for their cytotoxicity against selected human cancer cell lines. Some of the tested compounds exhibited promising carcinoma growth inhibition. The detailed synthesis, spectroscopic data and biological activities of the tested compounds were reported.

Key words

3, 4-dihydronaphthalene - enaminone - anticancer agents

Full Text

References

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