New approaches to inducing altitude acclimation in a relatively short timeframe are
needed, as it is not practical for many soldiers and athletes to gain access to specialized
training facilities. Acclimation to one environmental stressor could enhance adaptation
to various other stressors in animals and humans. This phenomenon has been described
as cross-tolerance and involves the activation of common protective pathways. The
purpose of this review is to discuss possible mechanisms involved in the cross-tolerance
between heat and hypoxia. Future data could potentially support the use of a cross-tolerance
model as a means for military personnel to prepare for deployment to high-altitude
environments, as well as for athletes competing at high altitude.
Key words
hypoxia - plasma volume - performance