Intraperitoneal Atrial Natriuretic Peptide Attenuates Anxiety-related Behaviour during Alcohol Withdrawal in Mice

C. von der Goltz; H. Jahn; J. Mutschler; K. Wiedemann; F. Kiefer

doi:10.1055/s-0034-1372645

Pharmacopsychiatry, Inhaltsverzeichnis

Pharmacopsychiatry 2014; 47(03): 97-100
DOI: 10.1055/s-0034-1372645

Original Paper

Intraperitoneal Atrial Natriuretic Peptide Attenuates Anxiety-related Behaviour during Alcohol Withdrawal in Mice

Autoren

C. von der Goltz

¹Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany
H. Jahn

²Department of Psychiatry, University Hospital of Hamburg, Hamburg, Germany
J. Mutschler

³Department of Psychiatry, Psychotherapy and Psychosomatics Center for Addictive Disorders, Zurich University Hospital of Psychiatry, Zurich, Switzerland
K. Wiedemann

²Department of Psychiatry, University Hospital of Hamburg, Hamburg, Germany
F. Kiefer

¹Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany

Abstract

Converging evidence from both preclinical and clinical studies suggests atrial natriuretic peptide (ANP) as a potential target for treatment of alcohol withdrawal and dependence. Since ANP tightly interacts with hypothalamic-pituitary-adrenocortical (HPA) axis activity, especially the modulation of stress-related anxiety during alcohol withdrawal might mediate these effects. We have now evaluated the anxiolytic activity of intraperitoneal ANP application during alcohol withdrawal in alcohol-habituated mice (C57/Bl6J). Anxiety related behaviour was attenuated during ethanol withdrawal following application of ANP (60 μg/kg) vs. saline. Our results support that anxiolytic effects of ANP mediate ANP-related gene effects with clinical data on withdrawal symptomatology.

Key words

ANP - alcoholism - HPA - natriuretic peptides - anxiety

Volltext

Referenzen

References
1 Treutlein J, Cichon S, Ridinger M et al. Genome-wide association study of alcohol dependence. Arch Gen Psychiatry 2009; 66: 773-784
2 Edenberg HJ, Koller DL, Xuei X et al. Genome-wide association study of alcohol dependence implicates a region on chromosome 11. Alcohol Clin Exp Res 2010; 34: 840-852
3 Kiefer F, Witt SH, Frank J et al. Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate. Pharmacogenomics 2011; 11: 368-374
4 Mutschler J, Bilbao A, von der Goltz C et al. Augmented stress-induced alcohol drinking and withdrawal in mice lacking functional natriuretic peptide-A receptors. Alcohol Alcohol 2010; 45: 13-16
5 Kiefer F, Andersohn F, Jahn H et al. Involvement of plasma atrial natriuretic peptide in protracted alcohol withdrawal. Acta Psychiatr Scand 2002; 105: 65-70
6 Hillemacher T, Frieling H, Luber K et al. Epigenetic regulation and gene expression of vasopressin and atrial natriuretic peptide in alcohol withdrawal. Psychoneuroendocrinology 2009; 34: 555-560
7 de Bold AJ. Atrial natriuretic factor: a hormone produced by the heart. Science 1985; 230: 767-770
8 Gianoulakis C, Guillaume P, Thavundayil J et al. Increased plasma atrialnatriuretic peptide after ingestion of low doses of ethanol in humans. Alcohol Clin Exp Res 1997; 21: 162-170
9 Antoni FA, Hunter EF, Lowry PJ et al. Atriopeptin: an endogenous corticotropin-release inhibiting hormone. Endocrinology 1992; 130: 1753-1755
10 Wiedemann K, Jahn H, Kellner M. Effects of natriuretic peptides upon hypothalamo-pituitary-adrenocortical system activity and anxiety behaviour. Exp Clin Endocrinol Diabetes 2000; 108: 5-13
11 Arlt J, Jahn H, Kellner M et al. Modulation of sympathetic activity by corticotropin-releasing hormone and atrial natriuretic peptide. Neuropeptides 2003; 37: 362-368
12 Fink G, Dow RC, Casley D et al. Atrial natriuretic peptide is a physiological inhibitor of ACTH release: evidence of rom immunoneutralization in vivo. J Endocrinol 1991; 131: R9-R12
13 Strohle A, Kellner M, Holsboer F et al. Anxiolytic activity of atrial natriuretic peptide in patients with panic disorder. Am J Psychiatry 2001; 158: 1514-1516
14 Wiedemann K, Jahn H, Yassouridis A et al. Anxiolytic like effects of atrialnatriuretic peptide on cholecystokinin tetrapeptide-induced panic attacks: preliminary findings. Arch Gen Psychiatry 2001; 58: 371-377
15 Timpl P, Spanagel R, Sillaber I et al. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nat Genet 1998; 19: 162-166
16 Heinz A, Rommelspacher H, Gräf KJ et al. Hypothalamic-pituitary-gonadal axis, prolactin, and cortisol in alcoholics during withdrawal and after three weeks of abstinence: comparison with healthy control subjects. PsychiatryRes 1995; 56: 81-95
17 Kiefer F, Wiedemann K. Neuroendocrine pathways of addictive behaviour. Addict Biol 2004; 9: 205-212
18 Välimäki M, Pelkonen R, Härkönen M et al. Hormonal changes in noncirrhotic male alcoholics during ethanol withdrawal. Alcohol Alcohol 1984; 19: 235-242
19 Kovacs GL. Natriuretic peptides in alcohol withdrawal: central and peripheral mechanisms. Curr Med Chem 2003; 10: 2559-2576
20 Kliethermes CL. Anxiety-like behaviors following chronic ethanol exposure. Neurosci Biobehav Rev 2005; 28: 837-850
21 Nakao K, Sugawara A, Morii N et al. The pharmacokinetics of alpha-human atrial natriuretic polypeptide in healthy subjects. Eur J Clin Pharmacol 1986; 31: 101-103
22 Jorde A, Bach P, Witt SH et al. Genetic variation in the atrial natriuretic peptide transcription factor GATA4 modulates amygdala responsiveness in alcohol dependence. Biol Psychiatry 2013; [Epub ahead of print]
23 Kienast T, Schlagenhauf F, Rapp MA et al. Dopamine-modulated aversive emotion processing fails in alcohol-dependent patients. Pharmacopsychiatry 2013; 46: 130-136