Rofo 2014; 186 - VO404_5
DOI: 10.1055/s-0034-1373326

ICG-based Optical Imaging Suggests Subclinical Involvement of Asymptomatic Joints in Psoriatic Arthritis but not in Arthrosis

K Tesch 1, C Kopetsch 1, F Sauer 1, R Zeuner 2, U Mrowietz 3, J Oltmann Schröder 2, O Jansen 1, M Both 1, A Wulff 1
  • 1UKSH Campus Kiel, Klinik für Radiologie und Neuroradiologie, Kiel
  • 2UKSH Campus Kiel, Klinik für Rheumatologie, Kiel
  • 3UKSH Campus Kiel, Klinik für Dermatologie, Kiel

Zielsetzung:

Swollen and tender joints of the hands can be caused by systemic arthritis or localised degenerative changes in activated arthrosis. Whereas in a systemic condition some involvement of asymptomatic joints is plausible, one would not expect such thing in arthrosis as there is no stimulus in unaffected joints. We investigated this phenomenon with ICG-based optical imaging.

Material und Methodik:

Nine patients (mean age 56,2a, 3 male, 5 with arthrosis) were clinically examined by an expert rheumatologist and underwent optical imaging (Xiralite X4, Mivenion, Berlin, Germany) after injection of ICG (Pulsion, Munich, Germany). Images were assessed using an in-house software. ROIs were drawn on clinically affected (n = 46) and unaffected (n = 22) joints by an expert reader. Intensity-time-curves were analysed with respect to the following parameters: Maximum intensity (max), time to peak (ttp), area under curve (auc) and rate of early enhancement (ree). Results were assessed by Wilcoxon rank sum test. A p < 0.05 was accepted to demonstrate statistical significance.

Ergebnisse:

Wilcoxon rank sum test yielded significant differences for the comparison of affected and unaffected joints in arthrosis for max (p = 0.045) and ttp (p = 0.013), but not for auc (p = 0.26) and ree (p = 0.56). There were no statistically significant differences in these comparisons for psoriatic arthritis. There were no statistically significant differences between affected joints in psoriatic arthritis and arthrosis (p ranging from 0.42 to 0.83).

Schlussfolgerungen:

We demonstrate statistically significant differences in affected and unaffected joints in arthrosis with regards to maximum signal intensity and time to peak, but not with respect to auc and ree. No such differences were present in psoriatic arthritis. We hypothesise the lack of these differences in psoriatic arthritis might be due to subclinical involvement of asymptomatic joints resulting in a slightly higher vascularisation as compared to unaffected joints in arthrotic hands.

E-Mail: k.ernst@rad.uni-kiel.de