Global Spine J 2014; 04(03): 137-142
DOI: 10.1055/s-0034-1376157
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Posterolateral Arthrodesis in Lumbar Spine Surgery Using Autologous Platelet-Rich Plasma and Cancellous Bone Substitute: An Osteoinductive and Osteoconductive Effect

Roberto Tarantino1, Pasquale Donnarumma1, Cristina Mancarella1, Marika Rullo2, Giancarlo Ferrazza3, Gianna Barrella3, Sergio Martini4, Roberto Delfini1
  • 1Department of Neurosurgery, “Sapienza” University of Rome, Rome, Italy
  • 2Department of Psychology of Developmental and Socialization Processes, “Sapienza” University of Rome, Rome, Italy
  • 3Department of Hematology, “Sapienza” University of Rome, Rome, Italy
  • 4Department of Neuroradiology, “Sapienza” University of Rome, Rome, Italy
Further Information

Publication History

26 January 2014

07 April 2014

Publication Date:
03 May 2014 (eFirst)


Study Design Prospective cohort study.

Objectives To analyze the effectiveness and practicality of using cancellous bone substitute with platelet-rich plasma (PRP) in posterolateral arthrodesis.

Methods Twenty consecutive patients underwent posterolateral arthrodesis with implantation of cancellous bone substitute soaked with PRP obtained directly in the operating theater on the right hemifield and cancellous bone substitute soaked with saline solution on the right.

Results Computed tomography scans at 6 and 12 months after surgery were performed in all patients. Bone density was investigated by comparative analysis of region of interest. The data were analyzed with repeated-measures variance analyses with value of density after 6 months and value of density after 12 months, using age, levels of arthrodesis, and platelet count as covariates. The data demonstrated increased bone density using PRP and heterologous cancellous block resulting in an enhanced fusion rate during the first 6 months after surgery.

Conclusions PRP used with cancellous bone substitute increases the rate of fusion and bone density joining osteoinductive and osteoconductive effect.