Synthesis 2015; 47(09): e3
DOI: 10.1055/s-0034-1378699
© Georg Thieme Verlag Stuttgart · New York

Efficient Synthesis of N-[4-(4-Chlorophenyl)butyl]-S-(3-piperidinopropyl)isothiourea (OUP-186) and Its Analogues Using 2-Nitrophenylacetyl Isothiocyanate: Application to Novel Histamine H3R Antagonists

Hiroki Yoneyama
Takuji Magata
Kenji Uemura
Yoshihide Usami
Satoshi Tanaka
Masanori Takaoka
Shinya Harusawa*
Further Information

Publication History

Publication Date:
20 April 2015 (online)

Please note that for the final print and online the following things were amended: An ‘i’ was added to the author name ‘Yoshihide Usami’; in the graphical abstract, IC50 was changed to pIC50; and in Tables 1, 4, and 5, the compound numbers were updated. �

Synthesis 2015, 47, 1291.