Synthesis of β-Trifluoromethylthio- and β-Trifluoromethylseleno-α,β-unsaturated Ketones through Copper-Mediated Trifluoromethylthio(seleno)lation

Chuanqi Hou; Xiaoxi Lin; Yangjie Huang; Zhirong Chen; Zhiqiang Weng

doi:10.1055/s-0034-1379972

Synthesis, Table of Contents

Synthesis 2015; 47(07): 969-975
DOI: 10.1055/s-0034-1379972

paper

Synthesis of β-Trifluoromethylthio- and β-Trifluoromethylseleno-α,β-unsaturated Ketones through Copper-Mediated Trifluoromethylthio(seleno)lation

Authors

Chuanqi Hou

Department of Chemistry, Fuzhou University, Fuzhou, 350108, P. R. of China Email: zweng@fzu.edu.cn
Xiaoxi Lin

Department of Chemistry, Fuzhou University, Fuzhou, 350108, P. R. of China Email: zweng@fzu.edu.cn
Yangjie Huang

Department of Chemistry, Fuzhou University, Fuzhou, 350108, P. R. of China Email: zweng@fzu.edu.cn
Zhirong Chen*

Department of Chemistry, Fuzhou University, Fuzhou, 350108, P. R. of China Email: zweng@fzu.edu.cn
Zhiqiang Weng*

Department of Chemistry, Fuzhou University, Fuzhou, 350108, P. R. of China Email: zweng@fzu.edu.cn

Abstract

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Abstract

An efficient and convenient synthetic methodology has been developed with which to construct β-trifluoromethylthio- and seleno-α,β-unsaturated ketones through copper-mediated trifluoromethylthio(seleno)lation of β-bromo α,β-unsaturated ketones. The corresponding ketone products were isolated in moderate to good yields and were efficiently converted into valuable alcohols.

Key words

fluorine - trifluoromethylthiolation - selenium - enones - copper

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References

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