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Synthesis 2015; 47(18): 2839-2843
DOI: 10.1055/s-0034-1381003
DOI: 10.1055/s-0034-1381003
paper
Iodofluorination of Alkenes Using IF5–Pyridine–HF
Further Information
Publication History
Received: 25 March 2015
Accepted after revision: 27 April 2015
Publication Date:
11 June 2015 (online)
Abstract
Iodofluorination of alkenes was performed by using IF5–pyridine–HF and a reductant such as potassium iodide or tin powder. The addition of IF to the double bond proceeded with stereo- and regioselectivity. In the reaction with internal alkenes, the trans-addition product was obtained selectively. With terminal alkenes, the addition took place regioselectively to give 1-iodo-2-fluoroalkanes.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1381003.
- Supporting Information
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As for the review articles of iodofluorination reaction, see: