Magnesium und kardiovaskuläre Gesundheit

Zusammenfassung

Magnesium hat vasodilatatorische, antientzündliche und antiarrhythmische Eigenschaften. Auch bei normalen Werten im Serum kann ein Magnesiummangel vorliegen. Die überwiegende Zahl der klinischen Studien zeigt deutlich eine Schutzwirkung von Magnesium auf kardiovaskuläre Erkrankungen und Risikofaktoren. Eine ausreichende Aufnahme von Magnesium sollte deshalb unbedingt erfolgen. Magnesiumhaltige Nahrungsmittel und Mineral- und Heilwässer sind wesentliche Bestandteile einer gesunden Ernährung und kardioprotektiven Lebensweise.

Schlüsselwörter

Magnesium - kardiovaskuläre Erkrankungen - Arteriosklerose - Hypertonie - Schlaganfall - Herzrhythmusstörungen

• Literatur

• 1 Adrian M, Chanut E, Laurant P et al. A long-term moderate magnesium-deficient diet aggravates cardiovascular risks associated with aging and increases mortality in rats. J Hypertens 2008; 26: 44-52
• 2 Del Gobbo LC, Imamura F, Wu JH et al. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies. Am J Clin Nutr 2013; 98: 160-173
• 3 Domke A, Grossklaus R, Niemann B et al. Use of minerals in foods: toxicological and nutritional physiological aspects. Berlin: Federal Institute for Risk Assessment; 2006
• 4 Elin RJ. Assessment of magnesium status for diagnosis and therapy. Magnes Res 2010; 23: S194-198
• 5 Everett CJ, King DE. Serum magnesium and the development of diabetes. Nutrition 2006; 22: 679
• 6 Ferre S, Baldoli E, Leidi M et al. Magnesium deficiency promotes a pro-atherogenic phenotype in cultured human endothelial cells via activation of NFkB. Biochim Biophys Acta 2010; 1802: 952-958
• 7 Fine KD, Santa Ana CA, Porter JL et al. Intestinal absorption of magnesium from food and supplements. J Clin Invest 1991; 88: 396-402
• 8 Hashimoto T, Hara A, Ohkubo T et al. Serum magnesium, ambulatory blood pressure, and carotid artery alteration: the Ohasama study. Am J Hypertens 2010; 23: 1292-1298
• 9 Khan AM, Lubitz SA, Sullivan LM et al. Low serum magnesium and the development of atrial fibrillation in the community: the Framingham Heart Study. Circulation 2013; 127: 33-38
• 10 Klevay LM, Milne DB. Low dietary magnesium increases supraventricular ectopy. Am J Clin Nutr 2002; 75: 550-554
• 11 Kolte D, Vijayaraghavan K, Khera S et al. Role of magnesium in cardiovascular diseases. Cardiol Rev 2014; 22: 182-192
• 12 Kousa A, Havulinna AS, Moltchanova E et al. Calcium:magnesium ratio in local groundwater and incidence of acute myocardial infarction among males in rural Finland. Environ Health Perspect 2006; 114: 730-734
• 13 Larsson SC, Orsini N, Wolk A. Dietary magnesium intake and risk of stroke: a meta-analysis of prospective studies. Am J Clin Nutr 2012; 95: 362-366
• 14 Levitan EB, Shikany JM, Ahmed A et al. Calcium, magnesium and potassium intake and mortality in women with heart failure: the Women’s Health Initiative. Br J Nutr 2013; 110: 179-185
• 15 Liebscher DH, Liebscher DE. About the misdiagnosis of magnesium deficiency. J Am Coll Nutr 2004; 23: 730S-731S
• 16 Malon A, Brockmann C, Fijalkowska-Morawska J et al. Ionized magnesium in erythrocytes – the best magnesium parameter to observe hypo- or hypermagnesemia. Clin Chim Acta 2004; 349: 67-73
• 17 Martini LA. Magnesium supplementation and bone turnover. Nutr Rev 1999; 57: 227-229
• 18 Nakamura E, Tai H, Uozumi Y et al. Magnesium absorption from mineral water decreases with increasing quantities of magnesium per serving in rats. Nutr Res 2012; 32: 59-65
• 19 Nielsen FH, Milne DB, Klevay LM et al. Dietary magnesium deficiency induces heart rhythm changes, impairs glucose tolerance, and decreases serum cholesterol in post menopausal women. J Am Coll Nutr 2007; 26: 121-132
• 20 Pham PC, Pham PA, Pham SV et al. Hypomagnesemia: a clinical perspective. Int J Nephrol Renovasc Dis 2014; 7: 219-230
• 21 Qu X, Jin F, Hao Y et al. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies. PLoS One 2013; 8 e57720
• 22 Rosanoff A. Changing crop magnesium concentrations: impact on human health. Plant and Soil 2013; 368: 139-153
• 23 Rylander R, Arnaud MJ. Mineral water intake reduces blood pressure among subjects with low urinary magnesium and calcium levels. BMC Public Health 2004; 4: 56
• 24 Sabatier M, Grandvuillemin A, Kastenmayer P et al. Influence of the consumption pattern of magnesium from magnesium-rich mineral water on magnesium bioavailability. Br J Nutr 2011; 106: 331-334
• 25 Sherer Y, Shoenfeld Y, Shaish A et al. Suppression of atherogenesis in female low-density lipoprotein receptor knockout mice following magnesium fortification of drinking water: the importance of diet. Pathobiology 2000; 68: 93-98
• 26 Song Y, Sesso HD, Manson JE et al. Dietary magnesium intake and risk of incident hypertension among middle-aged and older US women in a 10-year follow-up study. Am J Cardiol 2006; 98: 1616-1621
• 27 Verhas M, de la Gueronniere V, Grognet JM et al. Magnesium bioavailability from mineral water. A study in adult men. Eur J Clin Nutr 2002; 56: 442-447