Hodgkin lymphoma is a malignant tumor originating from lymphocytes that frequently
presents as a nodal lesion and rarely involves extranodal sites. The literature reports
only eight cases of primary Hodgkin lymphoma arising in oral mucosa and one of them
in the palatal mucosa, in the absence of nodal disease. We report a 43-year-old white
female patient with an unusual manifestation extranodal of primary Hodgkin lymphoma
in the hard palate with clinical aspects similar of other infections cutaneous mucosal
diseases. Analyses of infectious agents resulted negative. An incisional biopsy showed
lymphoplasmocitary infiltrate with presence of Hodgkin and Reed-Sternberg cells that
exhibited immunoreactivity for CD30 and Fascin and nonreactivity for CD15, CD45, CD56,
CD20, CD3, and TIA1, supporting a diagnosis of classical Hodgkin lymphoma clinical
stage according to Ann Arbor I-A. The patient was submitted to three cycles of chemotherapy
(ABVD, doxorubicin hydrochloride [Adriamycin], bleomycin sulfate, vinblastine sulfate,
and dacarbazine) and there was no evidence of diseases at 15 months of follow-up.
