Experimental and Clinical Endocrinology & Diabetes Reports 2014; 02(01): e4-e7
DOI: 10.1055/s-0034-1389902
Case Report
© Georg Thieme Verlag KG Stuttgart · New York

Autoimmune Thyroid Disease and Refractory Chronic Urticaria: Thyroidectomy as a Treatment for Long Standing Remission. A Case Report

C. Francés
1   Endocrinology and Nutrition Department
J. Nicolau
1   Endocrinology and Nutrition Department
M. García
2   Pathological Anatomy Department
C. Nadal
3   Dermatology Department, Hospital Son Llàtzer, Palma de Mallorca, Spain
L. A. Gómez
1   Endocrinology and Nutrition Department
L. Masmiquel
1   Endocrinology and Nutrition Department
› Author Affiliations
Further Information

Publication History

received 13 July 2014
first decision 13 July 2014

accepted 18 August 2014

Publication Date:
14 October 2014 (online)


The relationship between autoimmune thyroid disease and chronic autoimmune urticaria has been well established, even though the cause is still unknown. Several medical treatments have been proposed for chronic autoimmune urticaria, being antihistamines the first line. However, not all of the cases respond to this therapy, and other alternatives have been suggested, including corticosteroids, leukotriene antagonists or immunosuppressive drugs. Clinical improvement has also been reported after performing a thyroidectomy in 9 patients.

We present the case of a 36-year-old woman who developed a chronic autoimmune urticaria that did not respond to conservative treatment. During the initial study, she was diagnosed with a euthyroid autoimmune disease, that evolved into a subclinical hyperthyroidism 2 months later. Even though thyroid function was restored with anti-thyroid drugs, urticaria persisted, and finally it was decided to perform a thyroidectomy. After surgery, the patient stayed asymptomatic from the dermatological point of view, with no relapses more than 2 years later. Therefore, thyroidectomy is proposed as a new therapeutical option in patients with refractory chronic autoimmune urticaria.

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