Horm Metab Res 2015; 47(01): 16-23
DOI: 10.1055/s-0034-1389941
Review
© Georg Thieme Verlag KG Stuttgart · New York

Islet Cell Transplantation in Australia: Screening, Remote Transplantation, and Incretin Hormone Secretion in Insulin Independent Patients

C. S. Marathe
1   Endocrine & Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia
,
C. J. Drogemuller
2   Central Northern Adelaide Renal and Transplantation Service, and University of Adelaide at Royal Adelaide Hospital, Adelaide, Australia
,
J. A. Marathe
3   Department of Medicine, The Queen Elizabeth Hospital, Adelaide, Australia
,
T. Loudavaris
4   Department of Endocrinology and Diabetes, St Vincent’s Hospital and University of Melbourne, Melbourne, Australia
,
W. J. Hawthorne
5   National Pancreas Transplant Unit, University of Sydney at Westmead Hospital, Sydney, Australia
,
P. J. O’Connell
5   National Pancreas Transplant Unit, University of Sydney at Westmead Hospital, Sydney, Australia
,
T. Radford
2   Central Northern Adelaide Renal and Transplantation Service, and University of Adelaide at Royal Adelaide Hospital, Adelaide, Australia
,
T. W. H. Kay
4   Department of Endocrinology and Diabetes, St Vincent’s Hospital and University of Melbourne, Melbourne, Australia
,
M. Horowitz
1   Endocrine & Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia
,
P. T. Coates
2   Central Northern Adelaide Renal and Transplantation Service, and University of Adelaide at Royal Adelaide Hospital, Adelaide, Australia
,
D. J. Torpy
1   Endocrine & Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia
› Author Affiliations
Further Information

Publication History

received 08 July 2014

accepted 20 August 2014

Publication Date:
28 October 2014 (online)

Abstract

Islet cell transplantation has emerged as a treatment modality for type 1 diabetes in the last 15 years due to the Edmonton protocol leading to consistent and sustained exogenous insulin independence post-transplantation. In recent years, consortia that involve both local and remote islet cell centers have been established, with local centers responsible for processing and shipping of islet cells, and remote centers only transplanting them. There are, however, few data on patient outcomes at remote centers. A tendency for high fasting glucose despite insulin independence was noted by us and others with an unknown mechanism. This review provides a brief history of islet cell transplantation, and focuses on the South Australian remote center experience: the challenges, screening criteria, and the impact on incretin hormone secretion of insulin independent transplant patients.

 
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