Obstructive Sleep Apnea: Role of Intermittent Hypoxia and Inflammation

Anna M. May; Reena Mehra

doi:10.1055/s-0034-1390023

Seminars in Respiratory and Critical Care Medicine, Table of Contents

Semin Respir Crit Care Med 2014; 35(05): 531-544
DOI: 10.1055/s-0034-1390023

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Obstructive Sleep Apnea: Role of Intermittent Hypoxia and Inflammation

Authors

Anna M. May

¹Division of Pulmonary, Critical Care and Sleep Medicine, University Hospitals Case Medical Center, Cleveland, Ohio
Reena Mehra

²Neurologic Institute, Respiratory Institute, Heart and Vascular Institute and Lerner Research Institute, Cleveland Clinic Lerner College of Medicine of Case Western Research University, Cleveland Clinic Foundation, Cleveland, Ohio

Abstract

Obstructive sleep apnea results in intermittent hypoxia via repetitive upper airway obstruction leading to partial or complete upper airway closure, apneas and hypopneas, respectively. Intermittent hypoxia leads to sympathetic nervous system activation and oxidative stress with a resultant systemic inflammatory cascade. The putative mechanism by which obstructive sleep apnea has been linked to numerous pathologic conditions including stoke, cardiovascular disease, hypertension, and metabolic derangements is through these systemic effects. Treatment of obstructive sleep apnea appears to reduce systemic markers of inflammation and ameliorates the adverse sequelae of this disease.

Keywords

obstructive sleep apnea - inflammation - intermittent hypoxia - sympathetic nervous system activation

Full Text

References

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