Facial plast Surg 2014; 30(06): 670-675
DOI: 10.1055/s-0034-1396527
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

PRFM Enhance Wound Healing Process in Skin Graft

Mirta Reksodiputro1, Dini Widodo1, Jenny Bashiruddin1, Nurjati Siregar2, Safarina Malik3
  • 1Department of ENT, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
  • 2Department of Pathology Anatomy, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
  • 3Department of Biology Molecular, Eijkman Institute, Jakarta, Indonesia
Further Information

Publication History

Publication Date:
23 December 2014 (online)


Facial plastic and reconstructive surgery often used skin graft on defects that cannot be covered primarily by a local flap. However, wound healing using skin graft is slow, most of the time the graft is contractured and the take of graft is not optimal. Platelet rich fibrin matrix (PRFM) is a new generation of concentrated platelets that produce natural fibrin and reported to speed up the healing process. Application of PRFM in the skin graft implants is expected to increase the survival of the graft. We used porcine as animal models to elucidate the effect of autologous PRFM on wound healing in full-thickness (FTSG) and split-thickness (STSG) skin grafts. Survival level of the skin graft was determined by using ImageJ software based on the formation of collagen type 1 and graft take. We observed that the use of PRFM in FTSG and STSG increased type 1 collagen formation. We also found that PRFM addition in STSG gave the best skin graft take.