Facial Plast Surg 2014; 30(06): 599-614
DOI: 10.1055/s-0034-1396755
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Adverse Effects of Fillers and Their Histopathology

Eckart Haneke
1   Department of Dermatology, Inselspital, Universitätsspital Bern, Bern, Switzerland
› Author Affiliations
Further Information

Publication History

Publication Date:
23 December 2014 (online)

Abstract

Injectable fillers nowadays represent a pillar in facial rejuvenation and make a significant contribution to the success of the treatment. Despite their obvious benefits, a wide range of possible complications such as immediate, late, delayed, temporary, or irreversible adverse effects have to be respected. Differentiating the various filler materials, these effects are assigned to histopathology findings and currently available treatment options.

 
  • References

  • 1 Haneke E. Risks of permanent fillers. Expert Rev Dermatol 2009; 4: 271-283
  • 2 Haneke E. Skin rejuvenation without a scalpel. I. Fillers. J Cosmet Dermatol 2006; 5 (2) 157-167
  • 3 DeLorenzi C. Complications of injectable fillers, part I. Aesthet Surg J 2013; 33 (4) 561-575
  • 4 Ionescu A, Wutscher E, Brambilla E, Schneider-Feyrer S, Giessibl FJ, Hahnel S. Influence of surface properties of resin-based composites on in vitro Streptococcus mutans biofilm development. Eur J Oral Sci 2012; 120 (5) 458-465
  • 5 Haneke E. Soft tissue augmentation with injectable fillers and implants. In: Vuyk HD, Lohuis PJFM, , eds. Facial Plastic Surgery. London: Hodder Arnold; 2006: 167-180
  • 6 André P, Lowe NJ, Parc A, Clerici TH, Zimmermann U. Adverse reactions to dermal fillers: a review of European experiences. J Cosmet Laser Ther 2005; 7 (3-4) 171-176
  • 7 Cohen JL. Understanding, avoiding, and managing dermal filler complications. Dermatol Surg 2008; 34 (Suppl. 01) S92-S99
  • 8 Lazzeri D, Agostini T, Figus M, Nardi M, Pantaloni M, Lazzeri S. Blindness following cosmetic injections of the face. Plast Reconstr Surg 2012; 129 (4) 995-1012
  • 9 Park SW, Woo SJ, Park KH, Huh JW, Jung C, Kwon OK. Iatrogenic retinal artery occlusion caused by cosmetic facial filler injections. Am J Ophthalmol 2012; 154 (4) 653-662.e1
  • 10 Glaich AS, Cohen JL, Goldberg LH. Injection necrosis of the glabella: protocol for prevention and treatment after use of dermal fillers. Dermatol Surg 2006; 32 (2) 276-281
  • 11 Hirsch RJ, Cohen JL, Carruthers JD. Successful management of an unusual presentation of impending necrosis following a hyaluronic acid injection embolus and a proposed algorithm for management with hyaluronidase. Dermatol Surg 2007; 33 (3) 357-360
  • 12 Narins RS, Jewell M, Rubin M, Cohen J, Strobos J. Clinical conference: management of rare events following dermal fillers—focal necrosis and angry red bumps. Dermatol Surg 2006; 32 (3) 426-434
  • 13 Kleydman K, Cohen JL, Marmur E. Nitroglycerin: a review of its use in the treatment of vascular occlusion after soft tissue augmentation. Dermatol Surg 2012; 38 (12) 1889-1897
  • 14 Fulton J, Caperton C, Weinkle S, Dewandre L. Filler injections with the blunt-tip microcannula. J Drugs Dermatol 2012; 11 (9) 1098-1103
  • 15 Fiore II R, Miller R, Coffman SM. Mycobacterium mucogenicum infection following a cosmetic procedure with poly-L-lactic acid. J Drugs Dermatol 2013; 12 (3) 353-357
  • 16 Christensen L, Breiting V, Bjarnsholt T , et al. Bacterial infection as a likely cause of adverse reactions to polyacrylamide hydrogel fillers in cosmetic surgery. Clin Infect Dis 2013; 56 (10) 1438-1444
  • 17 Beljaards RC, de Roos KP, Bruins FG. NewFill for skin augmentation: a new filler or failure?. Dermatol Surg 2005; 31 (7 Pt 1) 772-776 , discussion 776
  • 18 Rohrich RJ, Monheit G, Nguyen AT, Brown SA, Fagien S. Soft-tissue filler complications: the important role of biofilms. Plast Reconstr Surg 2010; 125 (4) 1250-1256
  • 19 Gleeson CM, Lucas S, Langrish CJ, Barlow RJ. Acute fatal fat tissue embolism after autologous fat transfer in a patient with lupus profundus. Dermatol Surg 2011; 37 (1) 111-115
  • 20 Weinkle S. Efficacy and tolerability of admixing 0.3% lidocaine with Dermicol-P35 27G for the treatment of nasolabial folds. Dermatol Surg 2010; 36 (3) 316-320
  • 21 Sclafani AP, Romo III T. Collagen, human collagen, and fat: the search for a three-dimensional soft tissue filler. Facial Plast Surg 2001; 17 (1) 79-85
  • 22 Bassetto F, Turra G, Salmaso R, Lancerotto L, Del Vecchio DA. Autologous injectable dermis: a clinical and histological study. Plast Reconstr Surg 2013; 131 (4) 589e-596e
  • 23 Saray A. Porcine dermal collagen (Permacol) for facial contour augmentation: preliminary report. Aesthetic Plast Surg 2003; 27 (5) 368-375
  • 24 Monstrey SJ, Pitaru S, Hamdi M , et al. A two-stage phase I trial of Evolence30 collagen for soft-tissue contour correction. Plast Reconstr Surg 2007; 120 (1) 303-311
  • 25 Braun M, Braun S. Nodule formation following lip augmentation using porcine collagen-derived filler. J Drugs Dermatol 2008; 7 (6) 579-581
  • 26 Clark III CP. Animal-based hyaluronic acid fillers: scientific and technical considerations. Plast Reconstr Surg 2007; 120 (6, Suppl): 27S-32S
  • 27 Mummert ME. Immunologic roles of hyaluronan. Immunol Res 2005; 31 (3) 189-206
  • 28 Stern R, Asari AA, Sugahara KN. Hyaluronan fragments: an information-rich system. Eur J Cell Biol 2006; 85 (8) 699-715
  • 29 Wright AJ, Day AJ. Hyaluronan in immune processes. Adv Exp Med Biol 2005; 564: 57-69
  • 30 Goomer RS, Leslie K, Maris T, Amiel D. Native hyaluronan produces less hypersensitivity than cross-linked hyaluronan. Clin Orthop Relat Res 2005; (434) 239-245
  • 31 Enríquez Merino J. Perhidroescualeno y colágeno-polivinilpirrolidona: un nuevo matrial de relleno. Ensayo clínico con 20 pcientes. Dermatol Cosm Med Quir 2013; 11: 19-22
  • 32 Escobar Francisco SA, Rodríguez Ruiz XC. Tratamiento de surcos, depresiones cutáneas y líneas de expresión con perhidroescualeno CLG-PVP. Dermatol Cosm Méd Quir 2013; 11: 104-111
  • 33 Figueiredo VM. A five-patient prospective pilot study of a polycaprolactone based dermal filler for hand rejuvenation. J Cosmet Dermatol 2013; 12 (1) 73-77
  • 34 de Melo F, Marijnissen-Hofsté J. Investigation of physical properties of a polycaprolactone dermal filler when mixed with lidocaine and lidocaine/epinephrine. Dermatol Ther (Heidelb) 2012; 2 (1) 13
  • 35 Moulonguet I, de Goursac C, Plantier F. Granulomatous reaction after injection of a new resorbable filler Novabel. Am J Dermatopathol 2011; 33 (7) 710-711
  • 36 Niamtu III J. Filler injection with micro-cannula instead of needles. Dermatol Surg 2009; 35 (12) 2005-2008
  • 37 Rodriguez JM, Xie YL, Winthrop KL , et al. Mycobacterium chelonae facial infections following injection of dermal filler. Aesthet Surg J 2013; 33 (2) 265-269
  • 38 Grippaudo FR, Pacilio M, Di Girolamo M, Dierckx RA, Signore A. Radiolabelled white blood cell scintigraphy in the work-up of dermal filler complications. Eur J Nucl Med Mol Imaging 2013; 40 (3) 418-425
  • 39 Colbert SD, Southorn BJ, Brennan PA, Ilankovan V. Perils of dermal fillers. Br Dent J 2013; 214 (7) 339-340
  • 40 Alijotas-Reig J, Fernández-Figueras MT, Puig L. Inflammatory, immune-mediated adverse reactions related to soft tissue dermal fillers. Semin Arthritis Rheum 2013; 43 (2) 241-258
  • 41 Talbot SG, Parrett BM, Yaremchuk MJ. Sepsis after autologous fat grafting. Plast Reconstr Surg 2010; 126 (4) 162e-164e
  • 42 Sykes JM, Tapias V, Pu LL. Autologous fat grafting viability: lower third of the face. Facial Plast Surg 2010; 26 (5) 376-384
  • 43 Taupin A, Labbé D, Nicolas J, Debout C, Benateau H. Lipofilling and weight gain. Case report and review of the literature [in French]. Ann Chir Plast Esthet 2010; 55 (3) 238-242
  • 44 Delay E, Garson S, Tousson G, Sinna R. Fat injection to the breast: technique, results, and indications based on 880 procedures over 10 years. Aesthet Surg J 2009; 29 (5) 360-376
  • 45 Teimourian B. Blindness following fat injections. Plast Reconstr Surg 1988; 82 (2) 361
  • 46 Dreizen NG, Framm L. Sudden unilateral visual loss after autologous fat injection into the glabellar area. Am J Ophthalmol 1989; 107 (1) 85-87
  • 47 Egido JA, Arroyo R, Marcos A, Jiménez-Alfaro I. Middle cerebral artery embolism and unilateral visual loss after autologous fat injection into the glabellar area. Stroke 1993; 24 (4) 615-616
  • 48 Feinendegen DL, Baumgartner RW, Vuadens P , et al. Autologous fat injection for soft tissue augmentation in the face: a safe procedure?. Aesthetic Plast Surg 1998; 22 (3) 163-167
  • 49 Sclafani AP, Romo III T, Jacono AA, McCormick S, Cocker R, Parker A. Evaluation of acellular dermal graft in sheet (AlloDerm) and injectable (micronized AlloDerm) forms for soft tissue augmentation. Clinical observations and histological analysis. Arch Facial Plast Surg 2000; 2 (2) 130-136
  • 50 Requena L, Requena C, Christensen L, Zimmermann US, Kutzner H, Cerroni L. Adverse reactions to injectable soft tissue fillers. J Am Acad Dermatol 2011; 64 (1) 1-34 , quiz 35–36
  • 51 Tutrone WD, Cohen JL. Dissolving collagen fillers: enzymatic degradation of some problematic filler circumstances may now include collagens. J Drugs Dermatol 2009; 8 (12) 1140-1141
  • 52 André P. Evaluation of the safety of a non-animal stabilized hyaluronic acid (NASHA — Q-Medical, Sweden) in European countries: a retrospective study from 1997 to 2001. J Eur Acad Dermatol Venereol 2004; 18 (4) 422-425
  • 53 Rodrigues-Barata AR, Camacho-Martínez FM. Undesirable effects after treatment with dermal fillers. J Drugs Dermatol 2013; 12 (4) e59-e62
  • 54 Buntrock H, Reuther T, Prager W, Kerscher M. Efficacy, safety, and patient satisfaction of a monophasic cohesive polydensified matrix versus a biphasic nonanimal stabilized hyaluronic acid filler after single injection in nasolabial folds. Dermatol Surg 2013; 39 (7) 1097-1105
  • 55 Micheels P. Human anti-hyaluronic acid antibodies: is it possible?. Dermatol Surg 2001; 27 (2) 185-191
  • 56 Lupton JR, Alster TS. Cutaneous hypersensitivity reaction to injectable hyaluronic acid gel. Dermatol Surg 2000; 26 (2) 135-137
  • 57 Altman RD, Moskowitz R ; Hyalgan Study Group. Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. J Rheumatol 1998; 25 (11) 2203-2212
  • 58 Calvo M, Tornero P, De Barrio M , et al. Erytema multiform due to hyaluronic acid (go-on). J Investig Allergol Clin Immunol 2007; 17 (2) 127-128
  • 59 Brody HJ. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement. Dermatol Surg 2005; 31 (8, Pt 1) 893-897
  • 60 Bachmann F, Erdmann R, Hartmann V, Wiest L, Rzany B. The spectrum of adverse reactions after treatment with injectable fillers in the glabellar region: results from the Injectable Filler Safety Study. Dermatol Surg 2009; 35 (Suppl. 02) 1629-1634
  • 61 Schuller-Petrović S, Pavlović MD, Schuller SS, Schuller-Lukić B, Neuhold N. Early granulomatous foreign body reactions to a novel alginate dermal filler: the system's failure?. J Eur Acad Dermatol Venereol 2013; 27 (1) 121-123
  • 62 Eppley BL, Summerlin DJ, Prevel CD, Sadove AM. Effects of a positively charged biomaterial for dermal and subcutaneous augmentation. Aesthetic Plast Surg 1994; 18 (4) 413-416
  • 63 Massone C, Horn M, Kerl H, Ambros-Rudolph CM, Giovanna Brunasso AM, Cerroni L. Foreign body granuloma due to Matridex injection for cosmetic purposes. Am J Dermatopathol 2009; 31 (2) 197-199
  • 64 Huh SY, Cho S, Kim KH , et al. A case of complication after matridex(r) injection. Ann Dermatol 2010; 22 (1) 81-84
  • 65 Yang J-H, Lee SM, Won C-H , et al. Foreign body granuloma caused by hyaluronic acid/dextranomer microsphere filler injection. Int J Dermatol 2012; 51 (12) 1517-1518
  • 66 Apikian M, Roberts S, Goodman GJ. Adverse reactions to polylactic acid injections in the periorbital area. J Cosmet Dermatol 2007; 6 (2) 95-101
  • 67 Palm MD, Woodhall KE, Butterwick KJ, Goldman MP. Cosmetic use of poly-l-lactic acid: a retrospective study of 130 patients. Dermatol Surg 2010; 36 (2) 161-170
  • 68 Zimmermann US, Clerici TJ. The histological aspects of fillers complications. Semin Cutan Med Surg 2004; 23 (4) 241-250
  • 69 Marmur ES, Al Quran H, De Sa Earp AP, Yoo JY. A five-patient satisfaction pilot study of calcium hydroxylapatite injection for treatment of aging hands. Dermatol Surg 2009; 35 (12) 1978-1984
  • 70 Daines SM, Williams III EF. Complications associated with injectable soft-tissue fillers: a 5-year retrospective review. JAMA Facial Plast Surg 2013; 15 (3) 226-231
  • 71 Daley T, Damm DD, Haden JA, Kolodychak MT. Oral lesions associated with injected hydroxyapatite cosmetic filler. Oral Surg Oral Med Oral Pathol Oral Radiol 2012; 114 (1) 107-111
  • 72 Dadzie OE, Mahalingam M, Parada M, El Helou T, Philips T, Bhawan J. Adverse cutaneous reactions to soft tissue fillers—a review of the histological features. J Cutan Pathol 2008; 35 (6) 536-548
  • 73 Reddy KK, Brauer JA, Anolik R , et al. Calcium hydroxylapatite nodule resolution after fractional carbon dioxide laser therapy. Arch Dermatol 2012; 148 (5) 634-636
  • 74 Cohen JC, Reisacher W, Malone M, Sulica L. Severe systemic reaction from calcium hydroxylapatite vocal fold filler. Laryngoscope 2013; 123 (9) 2237-2239
  • 75 Christensen LH, Breiting VB, Aasted A, Jørgensen A, Kebuladze I. Long-term effects of polyacrylamide hydrogel on human breast tissue. Plast Reconstr Surg 2003; 111 (6) 1883-1890
  • 76 Leung KM, Yeoh GPS, Chan KW. Breast pathology in complications associated with polyacrylamide hydrogel (PAAG) mammoplasty. Hong Kong Med J 2007; 13 (2) 137-140
  • 77 Kalantar-Hormozi A, Mozafari N, Rasti M. Adverse effects after use of polyacrylamide gel as a facial soft tissue filler. Aesthet Surg J 2008; 28 (2) 139-142
  • 78 Reda-Lari A. Augmentation of the malar area with polyacrylamide hydrogel: experience with more than 1300 patients. Aesthet Surg J 2008; 28 (2) 131-138
  • 79 Cheng NX, Wang YL, Wang JH, Zhang XM, Zhong H. Complications of breast augmentation with injected hydrophilic polyacrylamide gel. Aesthetic Plast Surg 2002; 26 (5) 375-382
  • 80 Lee CJ, Kim SG, Kim L, Choi MS, Lee SI. Unfavorable findings following breast augmentation using injected polyacrylamide hydrogel. Plast Reconstr Surg 2004; 114 (7) 1967-1968
  • 81 Zarini E, Supino R, Pratesi G , et al. Biocompatibility and tissue interactions of a new filler material for medical use. Plast Reconstr Surg 2004; 114 (4) 934-942
  • 82 Malik S, Mehta P, Adesanya O, Ahluwalia HS. Migrated periocular filler masquerading as arteriovenous malformation: a diagnostic and therapeutic dilemma. Ophthal Plast Reconstr Surg 2013; 29 (1) e18-e20
  • 83 Jones DH, Carruthers A, Fitzgerald R, Sarantopoulos GP, Binder S. Late-appearing abscesses after injections of nonabsorbable hydrogel polymer for HIV-associated facial lipoatrophy. Dermatol Surg 2007; 33 (Suppl. 02) S193-S198
  • 84 Goldan O, Georgiou I, Grabov-Nardini G , et al. Early and late complications after a nonabsorbable hydrogel polymer injection: a series of 14 patients and novel management. Dermatol Surg 2007; 33 (Suppl. 02) S199-S206 , discussion S206
  • 85 Lemperle G, Morhenn V, Charrier U. Human histology and persistence of various injectable filler substances for soft tissue augmentation. Aesthetic Plast Surg 2003; 27 (5) 354-366 , discussion 367
  • 86 Bergeret-Galley C, Latouche X, Illouz YG. The value of a new filler material in corrective and cosmetic surgery: DermaLive and DermaDeep. Aesthetic Plast Surg 2001; 25 (4) 249-255
  • 87 Sidwell RU, Dhillon AP, Butler PE, Rustin MH. Localized granulomatous reaction to a semi-permanent hyaluronic acid and acrylic hydrogel cosmetic filler. Clin Exp Dermatol 2004; 29 (6) 630-632
  • 88 Angus JE, Affleck AG, Leach IH, Millard LG. Two cases of delayed granulomatous reactions to the cosmetic filler Dermalive, a hyaluronic acid and acrylic hydrogel. Br J Dermatol 2006; 155 (5) 1077-1078
  • 89 Rossner M, Rossner F, Bachmann F, Wiest L, Rzany B. Risk of severe adverse reactions to an injectable filler based on a fixed combination of hydroxyethylmethacrylate and ethylmethacrylate with hyaluronic acid. Dermatol Surg 2009; 35 (Suppl. 01) 367-374
  • 90 González-Vela MC, Armesto S, González-López MA, Fernández-Llaca JH, Val-Bernal JF. Perioral granulomatous reaction to Dermalive. Dermatol Surg 2008; 34 (7) 986-988
  • 91 Gamo R, Pinedo F, Vicente J , et al. Keratoacanthoma-like reaction after a hyaluronic acid and acrylic hydrogel cosmetic filler. Dermatol Surg 2008; 34 (7) 954-959
  • 92 Weyand B, Menke H. Case report: Adverse granulomatous reaction (granuloma formation) and pseudomonas superinfection after lip augmentation by the new filler DermaLive. Eur J Plast Surg 2008; 30: 291-295
  • 93 Hoffman AS. Synthetic polymeric biomaterials. In: Gebelein CG, , ed. Polymeric Materials and Artificial Organs. Washington, DC: American Chemical Society; 1984: 13-29
  • 94 Dansereau A, Hamilton D, Kavouni A , et al. A report on the safety of and satisfaction with particle-based fillers, specifically polymethylmethacrylate microspheres suspended in collagen. Cos Derm 2008; 21: 151-156
  • 95 Cohen SR, Berner CF, Busso M , et al. ArteFill: a long-lasting injectable wrinkle filler material—summary of the U.S. Food and Drug Administration trials and a progress report on 4- to 5-year outcomes. Plast Reconstr Surg 2006; 118 (Suppl. 03) S64-S76
  • 96 Solomon P, Sklar M, Zener R. Facial soft tissue augmentation with Artecoll(®): A review of eight years of clinical experience in 153 patients. Can J Plast Surg 2012; 20 (1) 28-32
  • 97 Haneke E. Polymethyl methacrylate microspheres in collagen. Semin Cutan Med Surg 2004; 23 (4) 227-232
  • 98 Wu W, Chayavichitsilp P, Hata T. Extremely delayed granulomatous reaction to soft-tissue injectables (polymethyl methacrylate). J Am Acad Dermatol 2012; 67 (5) e206-e207
  • 99 Fischer J, Metzler G, Schaller M. Cosmetic permanent fillers for soft tissue augmentation: a new contraindication for interferon therapies. Arch Dermatol 2007; 143 (4) 507-510
  • 100 Conejo-Mir JS, Sanz Guirado S, Angel Muñoz M. Adverse granulomatous reaction to Artecoll treated by intralesional 5-fluorouracil and triamcinolone injections. Dermatol Surg 2006; 32 (8) 1079-1081 , discussion 1082
  • 101 Odo ME, Odo LM, Nemoto NCF, Cucé LC. Treatment of nodules caused by polymethacrylate. A pilot study. Dermatol Surg 2008; 32: 1079-1081
  • 102 Kamoona B, Kazandjieva J, Balabanova M , et al. Oil soluble vitamins – unusual use as fillers for lip augmentation. 5th Summer Academy Dermatology Aesthetic Medicine; Sofia, Bulgaria; 2013
  • 103 Foucar E, Downing DT, Gerber WL. Sclerosing lipogranuloma of the male genitalia containing vitamin E: a comparison with classical “paraffinoma”. J Am Acad Dermatol 1983; 9 (1) 103-110
  • 104 Akkus E, Iscimen A, Tasli L, Hattat H. Paraffinoma and ulcer of the external genitalia after self-injection of vaseline. J Sex Med 2006; 3 (1) 170-172
  • 105 Nyirády P, Kelemen Z, Kiss A, Bánfi G, Borka K, Romics I. Treatment and outcome of vaseline-induced sclerosing lipogranuloma of the penis. Urology 2008; 71 (6) 1132-1137
  • 106 Al-Ansari AA, Shamsodini A, Talib RA, Gul T, Shokeir AA. Subcutaneous cod liver oil injection for penile augmentation: review of literature and report of eight cases. Urology 2010; 75 (5) 1181-1184
  • 107 Hohaus K, Bley B, Köstler E, Schönlebe J, Wollina U. Mineral oil granuloma of the penis. J Eur Acad Dermatol Venereol 2003; 17 (5) 585-587
  • 108 Maxwell GP, Gingrass MK. Ultrasound-assisted lipoplasty: a clinical study of 250 consecutive patients. Plast Reconstr Surg 1998; 101 (1) 189-202 , discussion 203–204
  • 109 Zocchi ML. Ultrasonic assisted lipoplasty. Technical refinements and clinical evaluations. Clin Plast Surg 1996; 23 (4) 575-598
  • 110 Seward AC, Meara DJ. Industrial-grade silicone injections causing intermittent bilateral malar swelling: review of safety and efficacy of techniques and products available. J Oral Maxillofac Surg 2013; 71 (7) 1245-1248
  • 111 Webster RC, Fuleihan NS, Hamadan US, Gaunt IM, Smith RC. Injectable silicone: report of 17,000 facial treatments since 1962. Am J Cosmet Surg 1986; 3: 41-48
  • 112 Benedetto AV, Lewis AT. Injecting 1000 centistoke liquid silicone with ease and precision. Dermatol Surg 2003; 29 (3) 211-214
  • 113 Zappi E, Barnett JG, Zappi M, Barnett CR. The long-term host response to liquid silicone injected during soft tissue augmentation procedures: a microscopic appraisal. Dermatol Surg 2007; 33 (Suppl. 02) S186-S192 , discussion S192
  • 114 Fulton J, Caperton C. The optimal filler: immediate and long-term results with emulsified silicone (1,000 centistokes) with cross-linked hyaluronic acid. J Drugs Dermatol 2012; 11 (11) 1336-1341
  • 115 Eppley BL, Sidner RA, Sadove AM. Adequate preclinical testing of bioplastique injectable material?. Plast Reconstr Surg 1992; 89 (1) 157-158
  • 116 Baijens L, Speyer R, Linssen M, Ceulen R, Manni JJ. Rejection of injectable silicone “Bioplastique” used for vocal fold augmentation. Eur Arch Otorhinolaryngol 2007; 264 (5) 565-568
  • 117 Ginat DT, Schatz CJ. Imaging of facial fillers: additional insights. AJNR Am J Neuroradiol 2012; 33 (11) E140-E141
  • 118 Grippaudo FR, Di Girolamo M, Mattei M, Pucci E, Grippaudo C. Diagnosis and management of dermal filler complications in the perioral region. J Cosmet Laser Ther 2014; 16 (5) 246-252
  • 119 El-Halaby A, Furtado Araújo MV. Unusual radiographic finding during routine periodontal maintenance: a case report. Tex Dent J 2014; 131 (4) 297-300
  • 120 Damrose EJ. Radiographic properties of injected calcium hydroxylapatite: potential false positive findings on positron emission tomography. J Laryngol Otol 2008; 122 (12) 1394-1396
  • 121 Feeney JN, Fox JJ, Akhurst T. Radiological impact of the use of calcium hydroxylapatite dermal fillers. Clin Radiol 2009; 64 (9) 897-902
  • 122 Ginat DT, Schatz CJ. Imaging features of midface injectable fillers and associated complications. AJNR Am J Neuroradiol 2013; 34 (8) 1488-1495
  • 123 Persichetti P, Palazzolo D, Tenna S, Poccia I, Abbruzzese F, Trombetta M. Dermal filler complications from unknown biomaterials: identification by attenuated total reflectance spectroscopy. Plast Reconstr Surg 2013; 131 (4) 597e-603e
  • 124 Eversole R, Tran K, Hansen D, Campbell J. Lip augmentation dermal filler reactions, histopathologic features. Head Neck Pathol 2013; 7 (3) 241-249
  • 125 Choi HJ. Pseudocyst of the neck after facial augmentation with liquid silicone injection. J Craniofac Surg 2014; 25 (5) e474-e475
  • 126 Wiest LG, Stolz W, Schroeder JA. Electron microscopic documentation of late changes in permanent fillers and clinical management of granulomas in affected patients. Dermatol Surg 2009; 35 (Suppl. 02) 1681-1688
  • 127 Reisberger EM, Landthaler M, Wiest L, Schröder J, Stolz W. Foreign body granulomas caused by polymethylmethacrylate microspheres: successful treatment with allopurinol. Arch Dermatol 2003; 139 (1) 17-20