Abstract
Object We aimed to investigate the clinical characters of congenital choledochal cysts (CC)
in perinatal patients and to determine the most suitable time for their management.
Study Design We retrospectively analyzed all the data of patients with CC in our hospital between
2003 and 2013. Clinical characteristics during the perinatal, infancy, and childhood
periods were examined.
Results A total of 216 cases were analyzed, including 12, 39, and 165 patients in their perinatal,
infancy, and childhood periods, respectively. The incidence of abdominal pain and
jaundice in the perinatal group was lower than that in other groups (p < 0.0001; p = 0.001). The incidence of abnormal inflammatory markers and liver function in perinatal
cases was lower than in the other cases (p = 0.012; p = 0.002). The receiver-operating characteristic curves for liver function indicated
that the cut-off point for age at which liver damage was found was 120 days. Of the
12 perinatal cases, there were no significant differences, with regards to operative
time and hospital stay, between open and laparoscopic surgical approaches (p = 0.164; p = 0.722).
Conclusion Abdominal pain, jaundice, inflammatory markers, and liver function in perinatal patients
with CC are better than in the infancy and childhood groups. We recommend surgical
treatment before 120 days of age.
Keywords
congenital choledochal cyst - liver function - perinatal - laparoscopic surgery
