Pneumologie 2015; 69 - P113
DOI: 10.1055/s-0035-1544845

Evolution of the prevalence and sensitivity pattern of streptococco pneumonia (penicillin and eritromycine) in the last eight years

EJS Hurtado 1, MJG Fernández 2, IG Romero 1, JMI Garcia 3, FC Rueda 1, AR Cantero 1, FJM de la Torre 4
  • 1Internal Medicine Service, Hospital La Serranía, Ronda (Malaga)
  • 2Microbiology Department, Laboratory Service, Hospital La Serrania
  • 3Pneumology Service, Hospital Quirón, Marbella
  • 4Laboratory Service, Hospital La Serrania

Introduction and objectives: There has been a significant increase in the rates of resistance of the main respiratory pathogens to the most commonly used antibiotics. Of special interest is the increase in the prevalence of resistance over the last decade to macrolide and penicillin in Streptococcus pneumoniae, the bacterial agent involved more frequently in respiratory infections. We have studied the prevalence and analyzed the evolution of the sensitivity of the isolated cultures with S. pneumoniae during the last eight years in our Hospital.

Method: We made a descriptive study with the data provided by the Service of Microbiology about the isolations of S. pneumoniae from 1997 to July 2014. The identification was carried out using sensitivity to optoquine and/or 32 gallery API rapid ID Strep (bioMérieux). The determination of the sensitivity was made through the disc-plate method and the E-test. Penicillin susceptibility was considered when MIC < 0,06 mcg/ml, intermediate 0,12 – 1 and resistant when ≥2. We analyzed number of total isolations, origin of the isolations, and sensitivity to the antimicrobials in every period and in general.

Result: A total of 409 isolations were obtained: 1997 – 1998: 37 isolations; 1999: 44; 2000: 29; 2001 – 2002: 56; 2003: 24; 2004: 27; 2005: 24; 2006: 21; 2007: 22. 2008: 10; 2009: 31; 2010: 34; 2011: 20; 2012: 16; 2013: 7 and 2014: 7.

The origin of the samples was: 83 exudates, 72 blood cultures, 68 sputum, 35 bronchoscopic aspiration, and 24 in other locations. Penicilin resistance (PR) and Eritromicine resistance (ER) were: 1997 – 2014: PR 65.7%; ER 38.2%; 1999: PR 34.1%, ER 43.2%; 2000: PR 38.5%; ER 48.3%; 2001 – 2002: PR 34.6%; ER 46.3%; 2003: PR 41.6%; ER 33.3; 2004: PR 44.4%; ER 44.4%; 2005: PR 16.6%; ER 33.3%; 2006: PR 9.5%; ER 14.2%; 2007: PR 12.5%; ER 17.2%; 2008: PR 0%: ER 0%; 2009:% PR 0%; ER 9.6%; 2010: PR 0%; ER 14.7%; 2011: PR: 5%; ER: 20%; 2012: PR: 6.25%; ER: 18.75%; 14.28%; 2013: PR 41% ER: and 2014: PR: 0% ER: 0%.

Conclusion:

  • The global average resistance in the analyzed period to penicilin was 24,3% and 35,8% for eritromicine.

  • Through the study we observed a decrease in resistance pattern. We saw an important reduction in the penicillin resistance to S pneumoniae in our area. Our results are similar to other studies, reaching in the last four years up to 12%. The reduction for eritromicin was up to 11,6%.