Pneumologie 2015; 69 - P299
DOI: 10.1055/s-0035-1544896

Cardiovascular magnetic resonance-guided diagnosis of cardiac affection in a Caucasian sarcoidosis population

C Pizarro 1, A Goebel 2, C Grohé 3, S Pabst 4, J Klein 1, G Nickenig 4, D Thomas 2, D Skowasch 4
  • 1Universitätsklinikum Bonn
  • 2Radiologische Klinik, Universitätsklinikum Bonn
  • 3Evangelische Lungenklinik Berlin
  • 4Medizinische Klinik II, Abteilung für Pneumologie und Kardiologie, Universitätsklinikum Bonn

Background: Clinically evidenced cardiac involvement in systemic sarcoidosis occurs in approximately 5% of patients, whereas post-mortem examinations identify cardiac sarcoidosis in over 60% of cases. Given the inconsistency of diagnostic approaches, we took aim at prospectively investigating the prevalence of cardiac sarcoidosis by cardiovascular magnetic resonance (CMR) in a Caucasian population and at correlating the results with standard clinical parameters.

Methods: 188 patients with histologically proven sarcoidosis were included, provenient from the local pneumological department and a national sarcoidosis self-help association. All of them underwent CMR-imaging. Complementary 12-lead ECG, Holter monitoring, laboratory and pulmonary function testing were performed.

Results: CMR-based diagnosis of cardiac sarcoidosis was made in 29 patients (15.4%), of whom 17 patients (9% of total cohort) exhibited increased relative gadolinium enhancement – reflecting acute inflammatory processes – while 11 patients (5.9% of total cohort) showed late gadolinium enhancement as a marker for nonviable tissue damage. Both abnormalities were present in 1 patient (0.5%). Correlation analysis evinced significant association between CMR-diagnosed cardiac sarcoidosis and reduction in LVEF, increase in diastolic interventricular septal thickness, diastolic dysfunction as well as limited electrocardiographic abnormalities. Neither laboratory values nor pulmonary function parameters correlated with presence or activity of cardiac sarcoidosis.

Conclusions: Among our predominantly Caucasian sarcoidosis study population, CMR-detected cardiac affection occurred in 15.4% and was missed by internationally valid standard clinical testing in all but one case. It reinforces CMR's diagnostic value as modality of choice to evaluate cardiac sarcoidosis. The estimation of its prognostic potential and its value in assessing CS-incidence however requires further longitudinal investigation.