Horm Metab Res 2015; 47(05): 321-328
DOI: 10.1055/s-0035-1547292
Review
© Georg Thieme Verlag KG Stuttgart · New York

Review of Current Surgical Techniques and Medical Management Considerations in the Treatment of Pediatric Patients with Disorders of Sex Development

M. DiSandro
1   Pediatric Urology, University of California, San Francisco, USA
,
D. P. Merke
2   NHI-Endocrinology, Bethseda, Maryland, USA
,
R. C. Rink
3   School of medicine, Pediatric Urology, Indiana University, Indianapolis, Indiana, USA
› Author Affiliations
Further Information

Publication History

received 20 October 2014

accepted 24 February 2015

Publication Date:
13 May 2015 (online)

 
  • References

  • 1 Whittam B, Rink RC. Treatment and Outcome of CAH: Current Reconstructive Surgery. In Genetic Steroid Disorders. New M, Lekarev O, Parsa A, Yuen T, O’Malley B, Hammer G. (eds.) Elsevier; Amsterdam: 2013: 279-284
  • 2 Hughes IA, Nihoul-Fekete C, Thomas B, Cohen-Kettenis PT. Consequences of the ESPE/LWPES guidelines for diagnosis and treatment of disorders of sex development. Best Pract Res Clin Endocrinol Metab 2007; 21: 351-365
  • 3 Speiser PW, Azziz R, Baskin LS, Ghizzoni L, Hensle TW, Merke DP, Meyer-Bahlburg HFL, Miller WL, Montori VM, Oberfield SE, Ritzen M, White PC. Congenital Adrenal Hyperplasia due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2010; 95: 4133-4160
  • 4 Lee PA, Houk CP, Ahmed SF, Hughes IA. Consensus statement on management of intersex disorders, International Consensus Conference on Intersex. Pediatrics 2006; 118: e488-e500
  • 5 Diamond M, Beh HG. Changes in the management of children with intersex conditions. Nat Clin Pract Endocrinol Metab 2008; 4: 4-5
  • 6 Looijenga LH, Hersmus R, Oosterbuis JW, Cools M, Drop SL, Wolffenbuttel KP. Tumor risk in disorders of sex development. Best Pract Res Clin Endocrinol Metab 2007; 21: 480-495
  • 7 Szybowska M. Assessing the informational needs of adolescents with a genetic condition: what do they want to know? J. Genet Couns 2007; 16: 201-210
  • 8 Consortium on the Management of Disorders of Sex Differentiation . Clinical Guidelines for the Management of Disorders of Sex Development in Childhood. Accord Alliance Rohnert Park: Intersex Society of North America; 2006
  • 9 Crouch NS, Creighton SM. Transition of care for adolescents with disorders of sex development. Nat Rev Endocrinol 2014; 10: 436-442
  • 10 Merke DP, Poppas DP. Management of adolescents with congenital adrenal hyperplasia. Lancet Diabetes and Endocrinol 2013; 1: 341-352
  • 11 Akbiyik F, Kutlu AO. External Genital Proportions in Prepubertal Girls: A Morphometric Reference for Female Genitoplasty. J Urol 2010; 184: 1476-1481
  • 12 Lloyd J, Crouch NS, Minto CL, Liao LM, Creighton SM. Female genital appearance: ‘normality’ unfolds. Br J Obstet Gynaecol 2005; 112: 643-646
  • 13 Ganesan A, Smith GH, Broome K, Steinberg A. Congenital adrenal hyperplasia: preliminary observations of the urethra in 9 cases. J Urol 2002; 167: 275-278
  • 14 Rink RC, Szymanski KM. Disorders of Sexual Development: Surgical Management. In Pediatric Urology: Contemporary Strategies From Fetal Life To Adolescence. Lima M, Manzoni G. (eds.) Berlin: Springer; 2014. in press
  • 15 Nordenskjold A, Holmdahl G, Frisen L, Falhammar H, Filipsson H, Thoren M, Janson PO, Hagenfeldt K. Type of mutation and surgical procedure affect long-term quality of life for women with congenital adrenal hyperplasia. J Clin Endocrinol Metab 2008; 93: 380-386
  • 16 “Surgical Management of Disorders of Sexual Differentiation, Cloacal Malformation, and Other Abnormalities of the Genitalia in Girls” . Campbell-Walsh Urology. 10th Edition Wein AJ. (ed.) Philadelphia, PA: Elsevier; 2011. Chap 134 3629-3666
  • 17 Pena A. Total urogenital mobilization: an easier way to repair cloacas. J Pediatr Surg 1997; 32: 267-268
  • 18 Rink RC, Metcalfe PD, Kaefer M, Casale AJ, Meldrum KK, Cain MP. Partial urogenital mobilization: A limited proximal dissection. J Pediatr Urol 2006; 3: 351
  • 19 Rink RC, Cain MP. Urogenital Mobilization for Urogenital Sinus Repair. BJU Int 2008; 102: 1182-1197
  • 20 Leslie JA, Cain MP, Rink RC. Feminizing genital reconstruction in congenital adrenal hyperplasia. Indian J Urol 2009; 25: 17-26
  • 21 Creighton S, Chernausek SD, Romao R, Ransley P, Salle JP. Timing and nature of reconstructive surgery for disorders of sex development – introduction. J Pediatr Urol 2012; 8: 602-610
  • 22 Baskin LS, Ebbers MB. Hypospadias: Anatomy, etiology, technique. J Pediatr Surg 2006; 41: 463-472
  • 23 Bluebond-Langner R, Redett RJ. Phalloplasty in complete aphallia and ambiguous genitalia. Semin Plast Surg 2011; 25: 196-205
  • 24 Springer A, Krois W, Horcher E. Trends in hypospadias surgery: results of a worldwide survey. Eur Urol 2011; 60: 1184-1189
  • 25 Herbst KW, Ferrer FA, Makari JH. The need for additional procedures in patients undergoing proximal hypospadias repairs as reported in the pediatric health information system database. J Urol 2013; 190 (4 Suppl) 1550-1555
  • 26 Hayashi Y, Kojima Y, Mizuno K, Tozawa K, Sasaki S, Kohri K. Modified technique of dorsal plication for penile curvature with or without hypospadias. Urology 2002; 59: 584-586
  • 27 De Win G, Cuckow P, Hoebeke P, Wood D. Long-term outcomes of pediatric hypospadias and surgical intervention. Ped Health Med Ther 2012; 3: 69-77
  • 28 Wilkinson DJ, Farrelly P, Kenny SE. Outcomes in distal hypospadias: a systematic review of the Mathieu and tubularized incised plate repairs. J Pediatr Urol 2012; 8: 307-312
  • 29 Lambert SM, Snyder HM, Canning DA. The history of hypospadias and hypospadias repairs. Urology 2011; 77: 1277-1283
  • 30 Spinoit AF, Poelaert F, Groen LA, Van Laecke E, Hoebeke P. Hypospadias repair at a tertiary care center: long-term followup is mandatory to determine the real complication rate. J Urol 2013; 189: 2276-2281
  • 31 Netto JM, Ferrarez CE, Schindler Leal AA, Tucci Jr S, Gomes CA, Barroso Jr U. Hormone therapy in hypospadias surgery: a systematic review. J Pediatr Urol. 2013; 9 (6 Pt B) 971-979
  • 32 Arshad AR. Hypospadias repair: Byar’s two stage operation revisited. Br J Plast Surg 2005; 58: 481-486
  • 33 Gershbaum MD, Stock JA, Hanna MK. A case for 2-stage repair of perineoscrotal hypospadias with severe chordee. J Urol 2002; 168 (4 Pt 2) 1727-1728
  • 34 Arena F, Romeo C, Manganaro A, Arena S, Zuccarello B, Romeo G. Surgical correction of penoscrotal transposition associated with hypospadias and bifid scrotum; our experience of two-stage repair. J Pediatr Urol 2005; 1: 289-294
  • 35 Fahmy MA, El Shennawy AA, Edress AM. Spectrum of penoscrotal positional anomalies in children. Int J Surg 2014; 12: 983-938
  • 36 Rink RC, Cain MP. Urogenital mobilization for urogenital sinus repair. BJU Int 2008; 102: 1182-1197
  • 37 Snodgrass W. Tubularized incised plate hypospadias repair: indications, technique, and complications. Urology 1999; 54: 6-11