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Aktuelle Neurologie 2015; 42(05): 247-255
DOI: 10.1055/s-0035-1548943
Neues in der Neurologie
© Georg Thieme Verlag KG Stuttgart · New York

Neues zu Kopfschmerzen 2015 – ein Update

What’s New in Headache 2015? – an Update
M. Obermann
1   Klinik für Neurologie und Westdeutsches Kopfschmerzzentrum, Universitätsklinikum Essen
,
D. Holle
2   Klinik für Neurologie, Universitätsklinikum Essen
,
S. Nägel
2   Klinik für Neurologie, Universitätsklinikum Essen
,
J. Burmeister
3   Klinik und Poliklinik für Neurologie, Universitätsklinikum Essen
,
K. Solbach
3   Klinik und Poliklinik für Neurologie, Universitätsklinikum Essen
,
H.-C. Diener
2   Klinik für Neurologie, Universitätsklinikum Essen
› Author Affiliations
Further Information

Publication History

Publication Date:
30 June 2015 (online)

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Zusammenfassung

Die neuesten und relevanten Informationen über Kopf- und Gesichtsschmerzen werden hier kurz und übersichtlich dargestellt. Eine Studie aus den USA konnte den Wert einer guten Anamnese und eines einfühlsamen, informativen Patientengespräches noch einmal unterstreichen. Gerade in der Schmerztherapie spielt eine gute und fundierte Aufklärung der Patienten über die geplante Therapie eine herausragende Rolle. Neue medikamentöse Therapieoptionen zur Behandlung der Migräne mit monoklonalen Antikörpern gegen den calcitonin-gene related peptide (CGRP) Rezeptor oder CGRP selbst haben die Phase-2-Studien erfolgreich beendet und machen nun einen weiteren Schritt in Richtung Patientenversorgung. Ein weiteres neues Medikament zur Behandlung der Trigeminusneuralgie hat die Phase-2-Studie erfolgreich beendet. Unterschiedliche Verfahren der Neuromodulation sind ebenfalls weiter „en vogue“ und werden in klinischen Studien, evidenzbasiert getestet. Hier ist die transkutane Stimulation des Nervus vagus besonders hervor zu heben, die sich in den folgenden Phase-3-Studien als einfach zu handhabende und wirksame Therapie erweisen könnte. Neben der Therapie werden auch neue pathophysiologische und klinisch-differenzialdiagnostische Erkenntnisse bei unterschiedlichen Kopfschmerzerkrankungen vorgestellt.

Abstract

A systematic review of the latest and most relevant information on different disorders of head and facial pain is presented. A study from the United States has highlighted the value of good history taking and a sensitive and informative patient dialogue. Especially in pain therapy, thorough patient education about the planned treatment approach plays a prominent role. New drug therapies for the treatment of migraine with monoclonal antibodies against the calcitonin gene-related peptide (CGRP) receptor or the CGRP itself showed promising results in the successfully completed phase-II-studies and represent a further step in patient care. A new drug for the treatment of trigeminal neuralgia has also successfully completed phase-II-trial. Different methods of neuromodulation remain “en vogue” and will be tested in evidence-based, clinical trials. Transcutaneous stimulation of the vagus nerve (tVNS) demonstrated its efficacy in cluster headache and migraine in early phase-II-studies and could prove to be an easy-to-use and effective therapy in phase-III-clinical trials. In addition to therapy options, new pathophysiological and differential diagnostic findings in different primary headache disorders are presented.

Schlüsselwörter

Kopfschmerzen - Migräne - Spannungskopfschmerz - Medikamentenübergebrauchskopfschmerz - Trigeminusneuralgie

Keywords

headache - migraine - tension-type headache - medication overuse headache - trigeminal neuralgia
 

  • Literatur

  • 1 Burch RC, Loder S, Loder E et al. The prevalence and burden of migraine and severe headache in the United States: updated statistics from government health surveillance studies. Headache 2015; 55: 21-34
    CrossrefPubMedGoogle Scholar
  • 2 Schramm SH, Moebus S, Lehmann N et al. The association between stress and headache: A longitudinal population-based study. Cephalalgia 2014; 34: 986-993
    CrossrefPubMedGoogle Scholar
  • 3 Bruffaerts R, Demyttenaere K, Kessler RC et al. The Associations Between Preexisting Mental Disorders and Subsequent Onset of Chronic Headaches: A Worldwide Epidemiologic Perspective. J Pain Off 2015; 16: 42-52
    PubMedGoogle Scholar
  • 4 Blaauw BA, Dyb G, Hagen K et al. The relationship of anxiety, depression and behavioral problems with recurrent headache in late adolescence – a Young-HUNT follow-up study. J Headache Pain 2015; 16: 10
    CrossrefPubMedGoogle Scholar
  • 5 Rist PM, Buring JE, Kurth T. Dietary patterns according to headache and migraine status: A cross-sectional study. Cephalalgia 2014; epub ahead of print
    PubMedGoogle Scholar
  • 6 Buettner C, Burstein R.. Association of statin use and risk for severe headache or migraine by serum vitamin D status: A cross-sectional population-based study. Cephalalgia 2014; epub ahead of print
    PubMedGoogle Scholar
  • 7 Lipton RB, Fanning KM, Serrano D et al. Ineffective acute treatment of episodic migraine is associated with new-onset chronic migraine. Neurology 2015; 84: 688-695
    CrossrefPubMedGoogle Scholar
  • 8 Wells RE, Markowitz SY, Baron EP et al. Identifying the Factors Underlying Discontinuation of Triptans. Headache J Head Face Pain 2014; 54: 278-289
    CrossrefPubMedGoogle Scholar
  • 9 Goadsby PJ, Grosberg BM, Mauskop A et al. Effect of noninvasive vagus nerve stimulation on acute migraine: An open-label pilot study. Cephalalgia 2014; 34: 986-993
    CrossrefPubMedGoogle Scholar
  • 10 Fujita M, Sato K, Nishioka H et al. Oral sumatriptan for migraine in children and adolescents: A randomized, multicenter, placebo-controlled, parallel group study. Cephalalgia 2014; 34: 365-375
    CrossrefPubMedGoogle Scholar
  • 11 Evers S. The efficacy of triptans in childhood and adolescence migraine. Curr Pain Headache Rep 2013; 17: 342
    CrossrefPubMedGoogle Scholar
  • 12 Tronvik E, Stovner LJ, Helde G et al. Prophylactic treatment of migraine with an angiotensin II receptor blocker: a randomized controlled trial. JAMA 2003; 289: 65-69
    CrossrefPubMedGoogle Scholar
  • 13 Stovner LJ, Linde M, Gravdahl GB et al. A comparative study of candesartan versus propranolol for migraine prophylaxis: A randomised, triple-blind, placebo-controlled, double cross-over study. Cephalalgia 2013; 34: 523-532
    PubMedGoogle Scholar
  • 14 Villalón CM, Olesen J. The role of CGRP in the pathophysiology of migraine and efficacy of CGRP receptor antagonists as acute antimigraine drugs. Pharmacol Ther 2009; 124: 309-323
    CrossrefPubMedGoogle Scholar
  • 15 Ho TW, Connor KM, Zhang Y et al. Randomized controlled trial of the CGRP receptor antagonist telcagepant for migraine prevention. Neurology 2014; 83: 958-966
    CrossrefPubMedGoogle Scholar
  • 16 Dodick DW, Goadsby PJ, Silberstein SD et al. Safety and efficacy of ALD403, an antibody to calcitonin gene-related peptide, for the prevention of frequent episodic migraine: a randomised, double-blind, placebo-controlled, exploratory phase 2 trial. Lancet Neurol 2014; 13: 1100-1107
    CrossrefPubMedGoogle Scholar
  • 17 Dodick DW, Goadsby PJ, Spierings ELH et al. Safety and efficacy of LY2951742, a monoclonal antibody to calcitonin gene-related peptide, for the prevention of migraine: a phase 2, randomised, double-blind, placebo-controlled study. Lancet Neurol 2014; 13: 885-892
    CrossrefPubMedGoogle Scholar
  • 18 Bigal ME, Escandon R, Bronson M et al. Safety and tolerability of LBR-101, a humanized monoclonal antibody that blocks the binding of CGRP to its receptor: Results of the Phase 1 program. Cephalalgia 2013; 34: 483-492
    PubMedGoogle Scholar
  • 19 Dilli E, Halker R, Vargas B et al. Occipital nerve block for the short-term preventive treatment of migraine: A randomized, double-blinded, placebo-controlled study. Cephalalgia 2014; epub ahead of print
    PubMedGoogle Scholar
  • 20 Conforto AB, Amaro E, Gonçalves AL et al. Randomized, proof-of-principle clinical trial of active transcranial magnetic stimulation in chronic migraine. Cephalalgia 2014; 34: 464-472
    CrossrefPubMedGoogle Scholar
  • 21 Bendtsen L, Munksgaard S, Tassorelli C et al. Disability, anxiety and depression associated with medication-overuse headache can be considerably reduced by detoxification and prophylactic treatment. Results from a multicentre, multinational study (COMOESTAS project). Cephalalgia 2014; 34: 426-433
    CrossrefPubMedGoogle Scholar
  • 22 Lipton RB, Serrano D, Nicholson RA et al. Impact of NSAID and Triptan use on developing chronic migraine: results from the American Migraine Prevalence and Prevention (AMPP) study. Headache 2013; 53: 1548-1563
    CrossrefPubMedGoogle Scholar
  • 23 Cargnin S, Viana M, Ghiotto N et al. Functional polymorphisms in COMT and SLC6A4 genes influence the prognosis of patients with medication overuse headache after withdrawal therapy. Eur J Neurol 2014; 21: 989-995
    CrossrefPubMedGoogle Scholar
  • 24 Cargnin S, Viana M, Sances G et al. Combined effect of common gene variants on response to drug withdrawal therapy in medication overuse headache. Eur J Clin Pharmacol 2014; 70: 1195-1202
    CrossrefPubMedGoogle Scholar
  • 25 Tassorelli C, Jensen R, Allena M et al. A consensus protocol for the management of medication-overuse headache: Evaluation in a multicentric, multinational study. Cephalalgia 2014; 34: 645-655
    CrossrefPubMedGoogle Scholar
  • 26 Kristoffersen ES, Straand J, Vetvik KG et al. Brief intervention for medication-overuse headache in primary care. The BIMOH study: a double-blind pragmatic cluster randomised parallel controlled trial. J Neurol Neurosurg Psychiatry 2015; 86: 505-512
    CrossrefPubMedGoogle Scholar
  • 27 Domingues RB, Duarte H, Rocha NP et al. Increased serum levels of interleukin-8 in patients with tension-type headache. Cephalalgia 2014; epub ahead of print
    PubMedGoogle Scholar
  • 28 D’Andrea G, D’Amico D, Bussone G et al. Tryptamine levels are low in plasma of chronic migraine and chronic tension-type headache. Neurol Sci 2014; 35: 1941-1945
    CrossrefPubMedGoogle Scholar
  • 29 Aaseth K, Grande RB, Lundqvist C et al. Pericranial tenderness in chronic tension-type headache: the Akershus population-based study of chronic headache. J Headache Pain 2014; 15: 58
    CrossrefPubMedGoogle Scholar
  • 30 Ashina S, Bendtsen L, Lyngberg AC et al. Prevalence of neck pain in migraine and tension-type headache: A population study. Cephalalgia 2015; 35: 211-219
    CrossrefPubMedGoogle Scholar
  • 31 Blaschek A, Decke S, Albers L et al. Self-reported neck pain is associated with migraine but not with tension-type headache in adolescents. Cephalalgia 2014; 34: 895-903
    CrossrefPubMedGoogle Scholar
  • 32 Engstrøm M, Hagen K, Bjørk M et al. Sleep quality, arousal and pain thresholds in tension-type headache: a blinded controlled polysomnographic study. Cephalalgia 2014; 34: 455-463
    CrossrefPubMedGoogle Scholar
  • 33 Chai NC, Scher AI, Moghekar A et al. Obesity and headache: part I – a systematic review of the epidemiology of obesity and headache. Headache 2014; 54: 219-234
    CrossrefPubMedGoogle Scholar
  • 34 Melhado EM, Bigal ME, Galego AR et al. Headache classification and aspects of reproductive life in young women. Arq Neuropsiquiatr 2014; 72: 17-23
    CrossrefPubMedGoogle Scholar
  • 35 Diener H-C, Gold M, Hagen M. Use of a fixed combination of acetylsalicylic acid, acetaminophen and caffeine compared with acetaminophen alone in episodic tension-type headache: meta-analysis of four randomized, double-blind, placebo-controlled, crossover studies. J Headache Pain 2014; 15: 76
    CrossrefPubMedGoogle Scholar
  • 36 Moore RA, Derry S, Wiffen PJ et al. Evidence for efficacy of acute treatment of episodic tension-type headache: Methodological critique of randomised trials for oral treatments. Pain 2014; 155: 2220-2228
    CrossrefPubMedGoogle Scholar
  • 37 Weinman D, Nicastro O, Akala O et al. Parenteral treatment of episodic tension-type headache: a systematic review. Headache 2014; 54: 260-268
    CrossrefPubMedGoogle Scholar
  • 38 Barbanti P, Egeo G, Aurilia C et al. Treatment of tension-type headache: from old myths to modern concepts. Neurol Sci 2014; 35 (Suppl. 01) 17-21
    CrossrefPubMedGoogle Scholar
  • 39 Espí-López GV, Rodríguez-Blanco C, Oliva-Pascual-Vaca A et al. Effect of manual therapy techniques on headache disability in patients with tension-type headache. Randomized controlled trial. Eur J Phys Rehabil Med 2014; 50: 641-647
    PubMedGoogle Scholar
  • 40 Gemma VE-L, Antonia G-C. Efficacy of manual and manipulative therapy in the perception of pain and cervical motion in patients with tension-type headache: a randomized, controlled clinical trial. J Chiropr Med 2014; 13: 4-13
    PubMedGoogle Scholar
  • 41 Rolle G, Tremolizzo L, Somalvico F et al. Pilot trial of osteopathic manipulative therapy for patients with frequent episodic tension-type headache. J Am Osteopath Assoc 2014; 114: 678-685
    PubMedGoogle Scholar
  • 42 Headache Classification Committee of the International Headache Society (IHS) . The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia 2013; 33: 629-808
    CrossrefPubMedGoogle Scholar
  • 43 Rossi P, Tassorelli C, Allena M et al. Focus on therapy: hemicrania continua and new daily persistent headache. J Headache Pain 2010; 11: 259-265
    CrossrefPubMedGoogle Scholar
  • 44 Peres MFP, Lucchetti G, Mercante JPP et al. New daily persistent headache and panic disorder. Cephalalgia Int J Headache 2011; 31: 250-253
    CrossrefPubMedGoogle Scholar
  • 45 Robbins MS. New daily-persistent headache and anxiety. Cephalalgia 2011; 31: 875-876
    PubMedGoogle Scholar
  • 46 Takase Y, Nakano M, Tatsumi C et al. Clinical features, effectiveness of drug-based treatment, and prognosis of new daily persistent headache (NDPH): 30 cases in Japan. Cephalalgia 2004; 24: 955-959
    CrossrefPubMedGoogle Scholar
  • 47 NORDIC Idiopathic Intracranial Hypertension Study Group Writing Committee . Wall M, McDermott MP et al. Effect of acetazolamide on visual function in patients with idiopathic intracranial hypertension and mild visual loss: the idiopathic intracranial hypertension treatment trial. JAMA 2014; 311: 1641-1651
    CrossrefPubMedGoogle Scholar
  • 48 Yri HM, Rönnbäck C, Wegener M et al. The course of headache in idiopathic intracranial hypertension: a 12-month prospective follow-up study. Eur J Neurol 2014; 21: 1458-1464
    CrossrefPubMedGoogle Scholar
  • 49 Wu C-J, Lian Y-J, Zheng Y-K et al. Botulinum toxin type A for the treatment of trigeminal neuralgia: results from a randomized, double-blind, placebo-controlled trial. Cephalalgia 2012; 32: 443-450
    CrossrefPubMedGoogle Scholar
  • 50 Zhang H, Lian Y, Ma Y et al. Two doses of botulinum toxin type A for the treatment of trigeminal neuralgia: observation of therapeutic effect from a randomized, double-blind, placebo-controlled trial. J Headache Pain 2014; 15: 65
    CrossrefPubMedGoogle Scholar
  • 51 Hagenacker T, Bude V, Naegel S et al. Patient-conducted anodal transcranial direct current stimulation of the motor cortex alleviates pain in trigeminal neuralgia. J Headache Pain 2014; 15: 78
    CrossrefPubMedGoogle Scholar
  • 52 Mitsikostas DD, Edvinsson L, Jensen RH et al. Refractory chronic cluster headache: a consensus statement on clinical definition from the European Headache Federation. J Headache Pain 2014; 15: 79
    CrossrefPubMedGoogle Scholar
  • 53 May A, Ashburner J, Büchel C et al. Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nat Med 1999; 5: 837
    PubMedGoogle Scholar
  • 54 Naegel S, Holle D, Obermann M. Structural Imaging in Cluster Headache. Curr Pain Headache Rep 2014; 18: 1-8
    PubMedGoogle Scholar
  • 55 Naegel S, Holle D, Desmarattes N et al. Cortical plasticity in episodic and chronic cluster headache. NeuroImage Clin 2014; 6: 415-423
    CrossrefPubMedGoogle Scholar
  • 56 Barloese M, Jennum P, Lund N et al. Reduced CSF hypocretin-1 levels are associated with cluster headache. Cephalalgia 2014; epub ahead of print
    PubMedGoogle Scholar
  • 57 Weller CM, Wilbrink LA, Houwing-Duistermaat JJ et al. Cluster headache and the hypocretin receptor 2 reconsidered: A genetic association study and meta-analysis. Cephalalgia 2014; epub ahead of print
    PubMedGoogle Scholar