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J Neurol Surg Rep 2015; 76(01): e128-e134
DOI: 10.1055/s-0035-1549227
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Primary Spinal Glioblastoma Multiforme with Secondary Manifestation as a Cerebral “Angioglioma.” Literature Review and Case Report

Thomas Linsenmann
1   Department of Neurosurgery, Julius-Maximilians-University, Würzburg, Germany
,
Thomas Westermaier
1   Department of Neurosurgery, Julius-Maximilians-University, Würzburg, Germany
,
Giles Hamilton Vince
2   Department of Neurosurgery, General Hospital of Klagenfurt, Austria
,
Camelia Maria Monoranu
3   Department of Neuropathology, Julius-Maximilians-University, Würzburg, Germany
,
Mario Löhr
1   Department of Neurosurgery, Julius-Maximilians-University, Würzburg, Germany
,
Ralf-Ingo Ernestus
1   Department of Neurosurgery, Julius-Maximilians-University, Würzburg, Germany
,
Christian Stetter
1   Department of Neurosurgery, Julius-Maximilians-University, Würzburg, Germany
› Author Affiliations
Further Information

Publication History

28 December 2014

04 February 2015

Publication Date:
13 May 2015 (online)

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Abstract

Primary intramedullary spinal glioblastoma multiforme (sGBM) with a secondary cerebral manifestation is a very rare entity with a poor outcome. Case studies show a mean average of survival of 10 months after diagnosis. These tumors tend to develop at a young age. A combination with an arteriovenous malformation in the same location has never been published before. Vascular malformations in association with cerebral glioblastomas have only been reported in five cases so far. Proangiogenic factors are assumed to be involved in the appearance of both entities. We present a case study and a review of the literature.

Keywords

spinal glioblastoma - cerebral angioglioma - arteriovenous malformation
 

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