Primary Spinal Glioblastoma Multiforme with Secondary Manifestation as a Cerebral “Angioglioma.” Literature Review and Case Report

Thomas Linsenmann; Thomas Westermaier; Giles Hamilton Vince; Camelia Maria Monoranu; Mario Löhr; Ralf-Ingo Ernestus; Christian Stetter

doi:10.1055/s-0035-1549227

Journal of Neurological Surgery Reports, Inhaltsverzeichnis

J Neurol Surg Rep 2015; 76(01): e128-e134
DOI: 10.1055/s-0035-1549227

Case Report

Georg Thieme Verlag KG Stuttgart · New York

Primary Spinal Glioblastoma Multiforme with Secondary Manifestation as a Cerebral “Angioglioma.” Literature Review and Case Report

Authors

Thomas Linsenmann

¹Department of Neurosurgery, Julius-Maximilians-University, Würzburg, Germany
Thomas Westermaier

¹Department of Neurosurgery, Julius-Maximilians-University, Würzburg, Germany
Giles Hamilton Vince

²Department of Neurosurgery, General Hospital of Klagenfurt, Austria
Camelia Maria Monoranu

³Department of Neuropathology, Julius-Maximilians-University, Würzburg, Germany
Mario Löhr

¹Department of Neurosurgery, Julius-Maximilians-University, Würzburg, Germany
Ralf-Ingo Ernestus

¹Department of Neurosurgery, Julius-Maximilians-University, Würzburg, Germany
Christian Stetter

¹Department of Neurosurgery, Julius-Maximilians-University, Würzburg, Germany

Abstract

Primary intramedullary spinal glioblastoma multiforme (sGBM) with a secondary cerebral manifestation is a very rare entity with a poor outcome. Case studies show a mean average of survival of 10 months after diagnosis. These tumors tend to develop at a young age. A combination with an arteriovenous malformation in the same location has never been published before. Vascular malformations in association with cerebral glioblastomas have only been reported in five cases so far. Proangiogenic factors are assumed to be involved in the appearance of both entities. We present a case study and a review of the literature.

Keywords

spinal glioblastoma - cerebral angioglioma - arteriovenous malformation

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Referenzen

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