Thorac Cardiovasc Surg 2016; 64(06): 526-532
DOI: 10.1055/s-0035-1550231
Original Thoracic
Georg Thieme Verlag KG Stuttgart · New York

Distribution and Prevalence of Locoregional Recurrence after Video-Assisted Thoracoscopic Surgery for Primary Lung Cancer

Tomohiro Haruki
1  Division of General Thoracic Surgery, Tottori University Hospital, Yonago, Tottori, Japan
,
Ken Miwa
1  Division of General Thoracic Surgery, Tottori University Hospital, Yonago, Tottori, Japan
,
Kunio Araki
1  Division of General Thoracic Surgery, Tottori University Hospital, Yonago, Tottori, Japan
,
Yuji Taniguchi
1  Division of General Thoracic Surgery, Tottori University Hospital, Yonago, Tottori, Japan
,
Hiroshige Nakamura
1  Division of General Thoracic Surgery, Tottori University Hospital, Yonago, Tottori, Japan
› Author Affiliations
Further Information

Publication History

29 January 2015

20 March 2015

Publication Date:
10 August 2015 (online)

Abstract

Background The aim of this study is to evaluate cases with locoregional recurrence after video-assisted thoracoscopic surgery (VATS) for primary lung cancer.

Methods We reviewed 248 patients with primary lung cancer who underwent lobectomy or segmentectomy with mediastinal lymph node dissection by VATS between January 2005 and December 2011. Locoregional recurrence is defined as per its occurrence in (1) bronchial stump or lung parenchymal cut end, (2) ipsilateral pleura, and (3) ipsilateral hilar and mediastinal lymph nodes, and we analyzed recurrence rate and significant associated factors for locoregional recurrence by logistic regression analysis.

Results There were 47 cases of postoperative recurrence, which consisted of 26 distant, 6 locoregional and distant, and 15 locoregional recurrences. The locoregional recurrence rate was 6.0%. Of the 15 locoregional recurrence cases, there were two cases of bronchial stump and lung parenchyma cut end (0.4%), five cases of ipsilateral pleura (2.0%), and eight cases of ipsilateral hilar and mediastinal lymph nodes (3.2%). Pleural and lymphovascular invasion and advanced stages were significant associated factors in univariate analysis. Multivariate analysis revealed that advanced stages were only a significant associated factor for locoregional recurrence (p < 0.01, odds ratio: 3.3).

Conclusion Although locoregional recurrence rates of our surgical treatments for primary lung cancer by VATS might be acceptable, we should explore more effective modalities against pathologically proven local advanced lung cancer for preventing not only distant but also locoregional recurrences.