Phys Med Rehab Kuror 2015; 25 - IS30
DOI: 10.1055/s-0035-1554842

Genetic and Molecular Mechanisms of Pain

S McMahon 1
  • 1King's College London, London, UK

Pain is a common and disabling feature of many disease states. It is frequently not well controlled by existing therapies. In this talk I will review the scope of the problem and some recent developments aimed at improving our understanding of the underlying mechanisms and treatment. In particular I will review our understanding of what molecular entities drive pain in damaged tissues and how these resulting signals are processed – and in many cases amplified – in the central nervous system. An important question is why people with apparently similar levels or disease or injury can experience very different amounts of pain. I will review how genetic and epigenetic processes might contribute to relative pain vulnerability or resilience.