Synthetic discoveries from polycyclic natural products

J May; JL Shih; TS Nguyen; P Le; R Vallakati; C Huynh; T Tran; S Jansone-Popova; BJ Lundy

doi:10.1055/s-0035-1556103

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Planta Med 2015; 81 - IL6
DOI: 10.1055/s-0035-1556103

Synthetic discoveries from polycyclic natural products

J May ¹, JL Shih ¹, TS Nguyen ¹, P Le ¹, R Vallakati ¹, C Huynh ¹, T Tran ¹, S Jansone-Popova ¹, BJ Lundy ¹

¹Department of Chemistry, University of Houston, 112 Fleming Building, Houston, Texas 77204 – 5003, United States

Congress Abstract

Complex polycyclic natural products present daunting challenges to the synthetic organic chemist and thus drive innovation. We have been inspired by the challenges presented by chiral indole alkaloid and bridged polycyclic natural products. We present new experimental results for enantioselective conjugate additions to generate alpha-chiral heterocycles and carbene cascade reactions to generate functionalized bridged bicycles. We also show the application of these methods to the total synthesis of these natural products.