Marine natural products synthesis as a driving force for chemical and biological discovery

Natural products bearing complex structures and potent biological activities have long been the target of chemical synthesis and have served as successful lead molecules for drug discovery. As part of our program centered on the synthesis and chemical biology of marine natural products we have achieved a rapid synthesis of synoxazolidinone A (1) and structural analogs. Through these efforts we have revealed new chemical reactions and potent lead structures for infectious disease research. The synthesis and chemical biology of the synoxazolidinones will be presented.