Journal of Pediatric Neurology 2003; 01(01): 035-038
DOI: 10.1055/s-0035-1557167
Original Article
Georg Thieme Verlag KG Stuttgart – New York

Serum beta 2-microglobulin and neopterin levels in children with febrile illness: their relation to influenza and febrile seizures

Akihisa Okumura
1   Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
,
Koji Takemoto
2   Department of Pediatrics, Konan Showa Hospital, Japan
,
Takao Ozaki
2   Department of Pediatrics, Konan Showa Hospital, Japan
› Author Affiliations

Subject Editor:
Further Information

Publication History

04 May 2003

18 June 2003

Publication Date:
29 July 2015 (online)

Abstract

The aim of this study is to evaluate serum beta 2-microglobulin and neopterin levels in children with febrile illness and to clarify their relation to influenza and febrile seizures (FS). We studied 34 patients with febrile illness whose age was between 1 and 6 years. Influenza A antigen in the throat swab was positive in 17 patients (Flu group) and was negative in 17 (control group). Serum levels of beta 2-microglobulin and neopterin were evaluated on admission. FS were observed in 13 patients (6 in Flu group and 7 in control group). Serum beta 2-microglobulin and neopterin levels were higher in Flu group than in control group. On the other hand, there were no significant differences in serum beta 2-microglobulin or neopterin levels between those with and without FS. Higher serum beta 2-microglobulin and neopterin levels in Flu group suggested that stronger activation of immune system was caused by influenza than by infection with other agents. (J Pediatr Neurol 2003; 1(1): 35–38).