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Journal of Pediatric Neurology 2008; 06(01): 047-051
DOI: 10.1055/s-0035-1557424
Case Report
Georg Thieme Verlag KG Stuttgart – New York

Hashimoto encephalopathy: A treatable cause of encephalopathy in children – further report of two cases

Akuma O. Akuma
a   Department of Pediatric Neurology, Bristol Royal Hospital for Sick Children, Bristol, UK
,
Peta M. Sharples
a   Department of Pediatric Neurology, Bristol Royal Hospital for Sick Children, Bristol, UK
,
Philip E. Jardine
a   Department of Pediatric Neurology, Bristol Royal Hospital for Sick Children, Bristol, UK
› Author Affiliations
Subject Editor:
Further Information

Publication History

26 April 2007

07 September 2007

Publication Date:
30 July 2015 (online)

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Abstract

Two teenage girls with episodic neuropsychiatric symptoms, altered consciousness, collapse and seizures requiring intensive care admissions are presented. Both were euthyroid at presentation and had markedly elevated anti-thyroperoxidase antibody. Extensive neurometabolic tests and cranial imaging were normal. However, psychometric testing showed evidence of memory and cognitive difficulties. Both were diagnosed as Hashimoto encephalopathy and one improved after steroid treatment while the other was lost to follow-up after defaulting scheduled elective hospital admission for steroid therapy.

Keywords

Hashimoto encephalopathy - antithyroid antibodies - status epilepticus