Download PDF
Journal of Pediatric Neurology 2008; 06(01): 053-056
DOI: 10.1055/s-0035-1557431
Case Report
Georg Thieme Verlag KG Stuttgart – New York

Glioblastoma multiforme incorrectly diagnosed as ADEM in children

Santosh R. Mordekar
a   Department of Pediatric Neurology, Queen's Medical Centre, Nottingham, UK
b   Department of Pediatric Neurology, Children's Hospital, Sheffield, UK
,
Christopher D. Rittey
b   Department of Pediatric Neurology, Children's Hospital, Sheffield, UK
,
Timothy Jaspan
c   Department of Neuroradiology, Queen's Medical Centre, Nottingham, UK
,
Daniel J. Connolly
d   Department of Neuroradiology, Children's Hospital, Sheffield, UK
,
William P. Whitehouse
a   Department of Pediatric Neurology, Queen's Medical Centre, Nottingham, UK
e   Academic Division of Child Health, University of Nottingham, Nottingham, UK
› Author Affiliations
Subject Editor:
Further Information

Publication History

19 March 2007

03 October 2007

Publication Date:
30 July 2015 (online)

Also available at
  PDF Download  Permissions and Reprints

Abstract

Acute disseminated encephalomyelitis is an acute demyelinating disorder of the central nervous system, characterized by an encephalopathy, multifocal grey matter and white matter involvement. Pediatric high-grade gliomas represent a heterogeneous group of tumors accounting for 15–20% of all pediatric brain tumors. We describe two children who were incorrectly diagnosed as acute disseminated encephalomyelitis initially, but subsequently found to have glioblastoma multiforme. The cases would exemplify the diagnostic difficulties in acute disseminated encephalomyelitis.

Keywords

ADEM - encephalopathy - glioma - children