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Journal of Pediatric Neurology 2008; 06(01): 053-056
DOI: 10.1055/s-0035-1557431
Case Report
Georg Thieme Verlag KG Stuttgart – New York

Glioblastoma multiforme incorrectly diagnosed as ADEM in children

Santosh R. Mordekar
a   Department of Pediatric Neurology, Queen's Medical Centre, Nottingham, UK
b   Department of Pediatric Neurology, Children's Hospital, Sheffield, UK
,
Christopher D. Rittey
b   Department of Pediatric Neurology, Children's Hospital, Sheffield, UK
,
Timothy Jaspan
c   Department of Neuroradiology, Queen's Medical Centre, Nottingham, UK
,
Daniel J. Connolly
d   Department of Neuroradiology, Children's Hospital, Sheffield, UK
,
William P. Whitehouse
a   Department of Pediatric Neurology, Queen's Medical Centre, Nottingham, UK
e   Academic Division of Child Health, University of Nottingham, Nottingham, UK
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19. März 2007

03. Oktober 2007

Publikationsdatum:
30. Juli 2015 (online)

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Abstract

Acute disseminated encephalomyelitis is an acute demyelinating disorder of the central nervous system, characterized by an encephalopathy, multifocal grey matter and white matter involvement. Pediatric high-grade gliomas represent a heterogeneous group of tumors accounting for 15–20% of all pediatric brain tumors. We describe two children who were incorrectly diagnosed as acute disseminated encephalomyelitis initially, but subsequently found to have glioblastoma multiforme. The cases would exemplify the diagnostic difficulties in acute disseminated encephalomyelitis.

Keywords

ADEM - encephalopathy - glioma - children