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Klin Monbl Augenheilkd 2015; 232(12): 1424-1427
DOI: 10.1055/s-0035-1558272
Statement
Georg Thieme Verlag KG Stuttgart · New York

Stellungnahme der Retinologischen Gesellschaft, der Deutschen Ophthalmologischen Gesellschaft und des Berufsverbands der Augenärzte Deutschlands zur Strahlentherapie bei neovaskulärer altersabhängiger Makuladegeneration[*]

September 2015 Deutsche Ophthalmologische Gesellschaft, Retinologische Gesellschaft, Berufsverband der Augenärzte Deutschlands
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Publication History

Publication Date:
17 December 2015 (online)

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In der Therapie der neovaskulären altersabhängigen Makuladegeneration (AMD) ist heute die intravitreale medikamentöse Therapie mit VEGF-Inhibitoren die Therapie der ersten Wahl [6]. Die entscheidende Verbesserung der Prognose der AMD wird allerdings durch viele intraokulare Injektionen und Untersuchungstermine und erhebliche Therapiekosten erkauft, sodass ein unvermindertes Interesse für alternative oder adjuvante Therapieformen in der Behandlung der AMD besteht. Die Strahlentherapie der neovaskulären AMD könnte dabei eine Option sein. Die potenziellen Bestrahlungstechniken und die aktuellen Ergebnisse sollen in dieser Stellungnahme dargestellt werden.

* Dieser Beitrag wird ebenfalls in der Zeitschrift Der Ophthalmologe, Springer Verlag, Berlin Heidelberg 2015, veröffentlicht.


 

  • Literatur

  • Archer DB, Gardiner TA. Ionizing radiation and the retina. Curr Opin Ophthalmol 1994; 5: 59-65
    PubMedSearch in Google Scholar
  • Balaiya S, Malyapa R, Hsi W. et al. Evaluation of proton beam radiation sensitivity of proliferating choroidal endothelial and retinal ganglion cells with clonogenic assay. Cutan Ocul Toxicol 2012; 31: 14-19
    CrossrefPubMedSearch in Google Scholar
  • Berson AM, Finger PT, Chakravarthy U. Radiation therapy for age-related macular degeneration. Semin Radiat Oncol 1999; 9: 155-162
    CrossrefPubMedSearch in Google Scholar
  • Chakravarthy U. Radiotherapy for choroidal neovascularisation of age-related macular degeneration: a fresh perspective. Eye (Lond) 2000; 14 (Pt 2) 151-154
    CrossrefPubMedSearch in Google Scholar
  • Chakravarthy U, Houston RF, Archer DB. Treatment of age-related subfoveal neovascular membranes by teletherapy: a pilot study. Br J Ophthalmol 1993; 77: 265-273
    CrossrefPubMedSearch in Google Scholar
  • Deutsche Ophthalmologische G. Die Anti-VEGF-Therapie bei der neovaskularen altersabhangigen Makuladegeneration – therapeutische Strategien: Stellungnahme der Deutschen Ophthalmologischen Gesellschaft, der Retinologischen Gesellschaft und des Berufsverbandes der Augenarzte Deutschlands – November 2014. Ophthalmologe 2015; 112: 237-245
    CrossrefPubMedSearch in Google Scholar
  • Dugel PU, Bebchuk JD, Nau J. et al. Epimacular brachytherapy for neovascular age-related macular degeneration: a randomized, controlled trial (CABERNET). Ophthalmology 2013; 120: 317-327
    CrossrefPubMedSearch in Google Scholar
  • Evans JR, Sivagnanavel V, Chong V. Radiotherapy for neovascular age-related macular degeneration. Cochrane Database Syst Rev 2010; 5: CD004004-CD004004
    PubMedSearch in Google Scholar
  • Finger PT, Berson A, Ng T. et al. Ophthalmic plaque radiotherapy for age-related macular degeneration associated with subretinal neovascularization. Am J Ophthalmol 1999; 127: 170-177
    CrossrefPubMedSearch in Google Scholar
  • Finger PT, Gelman YP, Berson AM. et al. Palladium-103 plaque radiation therapy for macular degeneration: results of a 7 year study. Br J Ophthalmol 2003; 87: 1497-1503
    CrossrefPubMedSearch in Google Scholar
  • Gertner M, Chell E, Pan KH. et al. Stereotactic targeting and dose verification for age-related macular degeneration. Med Phys 2010; 37: 600-606
    CrossrefPubMedSearch in Google Scholar
  • Gunduz K, Shields CL, Shields JA. et al. Radiation retinopathy following plaque radiotherapy for posterior uveal melanoma. Arch Ophthalmol 1999; 117: 609-614
    CrossrefPubMedSearch in Google Scholar
  • Hart PM, Chakravarthy U, Mackenzie G. et al. Visual outcomes in the subfoveal radiotherapy study: a randomized controlled trial of teletherapy for age-related macular degeneration. Arch Ophthalmol 2002; 120: 1029-1038
    CrossrefPubMedSearch in Google Scholar
  • Hokkanen J, Heikkonen J, Holmberg P. Theoretical calculations of dose distributions for beta-ray eye applicators. Med Phys 1997; 24: 211-213
    CrossrefPubMedSearch in Google Scholar
  • Holmes SM, Micka JA, Dewerd LA. Investigation of a 90Sr/90Y source for intra-ocular treatment of wet age-related macular degeneration. Med Phys 2009; 36: 4370-4378
    CrossrefPubMedSearch in Google Scholar
  • Holz FG, Engenhart R, Bellmann C. et al. Stereotactic radiation therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration. Front Radiat Ther Oncol 1997; 30: 238-246
    PubMedSearch in Google Scholar
  • Jaakkola A, Heikkonen J, Tommila P. et al. Strontium plaque brachytherapy for exudative age-related macular degeneration: three-year results of a randomized study. Ophthalmology 2005; 112: 567-573
    CrossrefPubMedSearch in Google Scholar
  • Jaakkola A, Heikkonen J, Tommila P. et al. Strontium plaque irradiation of subfoveal neovascular membranes in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 1998; 236: 24-30
    CrossrefPubMedSearch in Google Scholar
  • Jackson TL, Chakravarthy U, Kaiser PK. et al. Stereotactic radiotherapy for neovascular age-related macular degeneration: 52-week safety and efficacy results of the INTREPID study. Ophthalmology 2013; 120: 1893-1900
    CrossrefPubMedSearch in Google Scholar
  • Jackson TL, Chakravarthy U, Slakter JS. et al. Stereotactic radiotherapy for neovascular age-related macular degeneration: year 2 results of the INTREPID study. Ophthalmology 2015; 122: 138-145
    CrossrefPubMedSearch in Google Scholar
  • Jackson TL, Dugel PU, Bebchuk JD. et al. Epimacular brachytherapy for neovascular age-related macular degeneration (CABERNET): fluorescein angiography and optical coherence tomography. Ophthalmology 2013; 120: 1597-1603
    CrossrefPubMedSearch in Google Scholar
  • Jackson TL, Shusterman EM, Arnoldussen M. et al. Stereotactic radiotherapy for wet age-related macular degeneration (INTREPID): influence of baseline characteristics on clinical response. Retina 2015; 35: 194-204
    CrossrefPubMedSearch in Google Scholar
  • Kirwan JF, Constable PH, Murdoch IE. et al. Beta irradiation: new uses for an old treatment: a review. Eye (Lond) 2003; 17: 207-215
    CrossrefPubMedSearch in Google Scholar
  • Kumar B, Palimar P. Accelerated radiation retinopathy in diabetes and pregnancy. Eye (Lond) 2000; 14 (Pt 1) 107-108
    CrossrefPubMedSearch in Google Scholar
  • Mauget-Faysse M, Coquard R, Francais-Maury C. et al. Radiothérapie dans la dégénérescence maculaire liée a lʼage: facteurs de risque de survenue des complications, prévention et traitement des effets secondaires. J Fr Ophtalmol 2000; 23: 127-136
    PubMedSearch in Google Scholar
  • Moshfeghi DM, Kaiser PK, Gertner M. Stereotactic low-voltage x-ray irradiation for age-related macular degeneration. Br J Ophthalmol 2011; 95: 185-188
    CrossrefPubMedSearch in Google Scholar
  • Park SS, Daftari I, Phillips T. et al. Three-year follow-up of a pilot study of ranibizumab combined with proton beam irradiation as treatment for exudative age-related macular degeneration. Retina 2012; 32: 956-966
    CrossrefPubMedSearch in Google Scholar
  • Parsons JT, Bova FJ, Fitzgerald CR. et al. Radiation retinopathy after external-beam irradiation: analysis of time-dose factors. Int J Radiat Oncol Biol Phys 1994; 30: 765-773
    PubMedSearch in Google Scholar
  • Saric B, Sikic J, Katusic D. et al. Brachytherapy – optional treatment for choroidal neovascularization secondary to age-related macular degeneration. Coll Antropol 2001; 25 (Suppl.) 89-96
    PubMedSearch in Google Scholar
  • Schilling H, Sauerwein W, Friedrichs W. et al. Langzeitresultate der Strahlentherapie von Aderhauthämangiomen. Ophthalmologe 1996; 93: 154-157
    PubMedSearch in Google Scholar
  • Scott TA, Augsburger JJ, Brady LW. et al. Low dose ocular irradiation for diffuse choroidal hemangiomas associated with bullous nonrhegmatogenous retinal detachment. Retina 1991; 11: 389-393
    CrossrefPubMedSearch in Google Scholar
  • Senan S, Smit EF. Design of clinical trials of radiation combined with antiangiogenic therapy. Oncologist 2007; 12: 465-477
    CrossrefPubMedSearch in Google Scholar
  • The Radiation Therapy for Age-Related Macular Degeneration (Rad) Study Group. A prospective, randomized, double-masked trial on radiation therapy for neovascular age-related macular degeneration (RAD Study). Radiation Therapy for Age-related Macular Degeneration. Ophthalmology 1999; 106: 2239-2247
    CrossrefPubMedSearch in Google Scholar
  • Timke C, Zieher H, Roth A. et al. Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves radiation tumor therapy. Clin Cancer Res 2008; 14: 2210-2219
    CrossrefPubMedSearch in Google Scholar
  • Zambarakji HJ, Lane AM, Ezra E. et al. Proton beam irradiation for neovascular age-related macular degeneration. Ophthalmology 2006; 113: 2012-2019
    CrossrefPubMedSearch in Google Scholar