Dialyse aktuell 2015; 19(06): 336-337
DOI: 10.1055/s-0035-1559835
Forum der Industrie
Georg Thieme Verlag KG Stuttgart · New York

Zitrat-Locklösungen für Hämodialysekatheter – Weniger Infektionen und Thrombenbildungen als unter Heparin

Further Information

Publication History

Publication Date:
10 August 2015 (online)

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Um einen zentralen Dialysekatheter durchgängig zu halten, ist die Installation (Lock) eines Antikoagulans in jedes Lumen notwendig. Wie kontrollierte Studien zeigen, haben zitrathaltige Locklösungen gegenüber Heparin teilweise signifikante Vorteile. Damit können katheterassoziierte Infektionen, Thrombenbildungen und Blutungskomplikationen reduziert werden.

 

  • Literatur

  • 1 von Gersdorff G. DOPPS Annual Report 2013. Poster DGfN-Kongress 2013
    Google Scholar
  • 2 Allon M. Dialysis catheter-related bacteremia: treatment and prophylaxis. Am J Kidney Dis 2004; 44: 779-791
    CrossrefGoogle Scholar
  • 3 Bleyer AJ. Clin J Am Soc Nephrol 2007; 2: 1073-1078
    Crossref
  • 4 Shanks RM, Donegan NP, Graber ML et al. Heparin stimulates Staphylococcus aureus biofilm formation. Infect Immun 2005; 73: 4596-4606
    CrossrefPubMedGoogle Scholar
  • 5 Weijmer MC, Debets-Ossenkopp YJ, Van De Vondervoort FJ, ter Wee PM et al. Superior antimicrobial activity of trisodium citrate over heparin for catheter locking. Nephrol Dial Transplant 2002; 17: 2189-2195
    CrossrefGoogle Scholar
  • 6 Bosma JW, Siegert CE, Peerbooms PG, Weijmer MC. Reduction of biofilm formation with trisodium citrate in haemodialysis catheters: a randomized controlled trial. Nephrol Dial Transplant 2010; 25: 1213-1217
    CrossrefGoogle Scholar
  • 7 Karaaslan H, Peyronnet P, Benevent D et al. Risk of heparin lock-related bleeding when using indwelling venous catheter in haemodialysis. Nephrol Dial Transplant 2001; 16: 2072-2074
    CrossrefGoogle Scholar
  • 8 Weijmer MC, van den Dorpel MA, Van de Ven PJ et al. Randomized, clinical trial comparison of trisodium citrate 30% and heparin as catheter-locking solution in hemodialysis patients. J Am Soc Nephrol 2005; 16: 2769-2777
    CrossrefGoogle Scholar
  • 9 Ash SR, Mankus RA, Sutton JM et al. Concentrated sodium citrate (23%) for catheter lock. Hemodial Int 2000; 4: 22-31
    Google Scholar
  • 10 Van Der Meersch H, De Bacquer D, Vandecasteele SJ et al. Hemodialysis catheter design and catheter performance: a randomized controlled trial. Am J Kidney Dis 2014; 64: 902-908
    CrossrefGoogle Scholar
  • 11 Winnett G, Nolan J, Miller M, Ashman N. Trisodium citrate 46.7% selectively and safely reduces staphylococcal catheter-related bacteraemia. Nephrol Dial Transplant 2008; 23: 3592-3598
    CrossrefGoogle Scholar
  • 12 Yon CK, Low CL. Sodium citrate 4% versus heparin as a lock solution in hemodialysis patients with central venous catheters. Am J Health Syst Pharm 2013; 70: 131-136
    CrossrefGoogle Scholar
  • 13 Vanholder R, Canaud B, Fluck R et al. Diagnosis, prevention and treatment of haemodialysis catheter-related bloodstream infections (CRBSI): a position statement of European Renal Best Practice (ERBP). NDT Plus 2010; 3: 234-246
    Google Scholar