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J Neurol Surg Rep 2015; 76(02): e227-e232
DOI: 10.1055/s-0035-1560048
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Third Ventricular Glioblastoma Multiforme: Case Report and Literature Review

Omid R. Hariri
1   Department of Neurosurgery, Arrowhead Regional Medical Center, Colton, California, United States
2   Department of Neurosurgery, Institute of Clinical Orthopedics and Neurosciences, Desert Regional Medical Center, Palm Springs, California, United States
,
Syed A. Quadri
1   Department of Neurosurgery, Arrowhead Regional Medical Center, Colton, California, United States
2   Department of Neurosurgery, Institute of Clinical Orthopedics and Neurosciences, Desert Regional Medical Center, Palm Springs, California, United States
,
Saman Farr
3   Division of Neurosurgery, Department of Surgery, College of Osteopathic Medicine, Western University of Health Sciences, Pomona, California, United States
,
Ravi Gupta
4   Department of Radiology, Harbor-UCLA Medical Center, Torrance, California, United States
,
Andrew J. Bieber
1   Department of Neurosurgery, Arrowhead Regional Medical Center, Colton, California, United States
2   Department of Neurosurgery, Institute of Clinical Orthopedics and Neurosciences, Desert Regional Medical Center, Palm Springs, California, United States
,
Anya Dyurgerova
3   Division of Neurosurgery, Department of Surgery, College of Osteopathic Medicine, Western University of Health Sciences, Pomona, California, United States
,
Casey Corsino
3   Division of Neurosurgery, Department of Surgery, College of Osteopathic Medicine, Western University of Health Sciences, Pomona, California, United States
,
Dan Miulli
1   Department of Neurosurgery, Arrowhead Regional Medical Center, Colton, California, United States
,
Javed Siddiqi
1   Department of Neurosurgery, Arrowhead Regional Medical Center, Colton, California, United States
2   Department of Neurosurgery, Institute of Clinical Orthopedics and Neurosciences, Desert Regional Medical Center, Palm Springs, California, United States
› Author Affiliations
Further Information

Publication History

13 November 2014

12 June 2015

Publication Date:
04 August 2015 (online)

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Abstract

Background Glioblastoma multiforme (GBM) typically presents in the supratentorial white matter, commonly within the centrum semiovale as a ring-enhancing lesion with areas of necrosis. An atypical presentation of this lesion, both anatomically as well as radiographically, is significant and must be part of the differential for a neoplasm in this anatomical location.

Case Description We present a case of a 62-year-old woman with headaches, increasing somnolence, and cognitive decline for several weeks. Magnetic resonance imaging demonstrated mild left ventricular dilatation with a well-marginated, homogeneous, and nonhemorrhagic lesion located at the ceiling of the third ventricle within the junction of the septum pellucidum and fornix, without exhibiting the typical radiographic features of hemorrhage or necrosis. Final pathology reports confirmed the diagnosis of GBM.

Conclusion This case report describes an unusual location for the most common primary brain neoplasm. Moreover, this case identifies the origin of a GBM related to the paracentral ventricular structures infiltrating the body of the fornix and leaves of the septum pellucidum. To our knowledge this report is the first reported case of a GBM found in this anatomical location with an entirely atypical radiographic presentation.

Keywords

glioblastoma multiforme - third ventricle - foramen of Monroe - gliosarcoma - septum pellucidum - hydrocephalus - fornix
 

  • References

  • 1 Mohin G, Madajewicz S, Mazione J , et al. Glioblastoma multiforme: advances in postsurgical management. Community Oncol 2006; 3 (10) 678-683
    CrossrefPubMedGoogle Scholar
  • 2 Moiyadi A, Sridhar E, Jalali R. Intraventricular gliosarcoma: unusual location of an uncommon tumor. J Neurooncol 2010; 96 (2) 291-294
    CrossrefPubMedGoogle Scholar
  • 3 Prakash O, Lukiw WJ, Peruzzi F, Reiss K, Musto AE. Gliomas and seizures. Med Hypotheses 2012; 79 (5) 622-626
    CrossrefPubMedGoogle Scholar
  • 4 Rees JH, Smirniotopoulos JG, Jones RV, Wong K. Glioblastoma multiforme: radiologic-pathologic correlation. Radiographics 1996; 16 (6) 1413-1438 ; quiz 1462–1463
    CrossrefPubMedGoogle Scholar
  • 5 Stark AM, Nabavi A, Mehdorn HM, Blömer U. Glioblastoma multiforme—report of 267 cases treated at a single institution. Surg Neurol 2005; 63 (2) 162-169 ; discussion 169
    CrossrefPubMedGoogle Scholar
  • 6 Vougiouklakis T, Mitselou A, Agnantis NJ. Sudden death due to primary intracranial neoplasms. A forensic autopsy study. Anticancer Res 2006; 26 (3B): 2463-2466
    PubMedGoogle Scholar
  • 7 Wen PY, Kesari S. Malignant gliomas in adults. N Engl J Med 2008; 359 (5) 492-507
    CrossrefPubMedGoogle Scholar
  • 8 Whitley RJ, Markert JM. Viral therapy of glioblastoma multiforme. Proc Natl Acad Sci U S A 2013; 110 (29) 11672-11673
    CrossrefPubMedGoogle Scholar
  • 9 Lee TT, Manzano GR. Third ventricular glioblastoma multiforme: case report. Neurosurg Rev 1997; 20 (4) 291-294
    CrossrefPubMedGoogle Scholar
  • 10 Glastonbury CM, Osborne AG, Salzman KL. Masses and malformations of the third ventricle: normal anatomic relationships and differential diagnoses. Radiographics 2011; 31 (7) 1889-1905
    CrossrefPubMedGoogle Scholar
  • 11 McKean-Cowdin R, Razavi P, Barrington-Trimis J , et al. Trends in childhood brain tumor incidence: 1973–2009. J Neurooncol 2013; 115 (2) 153-160
    CrossrefPubMedGoogle Scholar
  • 12 Patel DM, Schmidt RF, Liu JK. Update on the diagnosis, pathogenesis, and treatment strategies for central neurocytoma. J Clin Neurosci 2013; 20 (9) 1193-1199
    CrossrefPubMedGoogle Scholar
  • 13 Kim YJ, Lee SK, Cho MK, Kim YJ. Intraventricular glioblastoma multiforme with previous history of intracerebral hemorrhage : a case report. J Korean Neurosurg Soc 2008; 44 (6) 405-408
    CrossrefPubMedGoogle Scholar
  • 14 Park DeWitt J, Kim YH, Han JH , et al. Primary intracranial germ cell tumor originating from septum pellucidum that mimics central neurocytoma. J Clin Oncol 2012; 30 (27) e274-e277
    CrossrefPubMedGoogle Scholar
  • 15 Hasso A, Shakudo M, Chadrycki E, . In: Lufkin RB, Bradley WG, Brant-Zawadki M. , eds. MRI of the Brain III: Neoplastic Disease (The Raven MRI Teaching File series). New York, NY: Raven Press; 1991
    Google Scholar
  • 16 Yasargil MG. Intraventricular tumors. Microneurosurgery of CNS Tumors. Vol. 4B. New York, NY: Thieme Medical Publishers; 1996: 313-342
    Google Scholar
  • 17 Albert Lasierra P. Tumores y otros procesos de la parte anterior del III ventrıculo. Neurocirugia 1999; 10: 27-41
    PubMedGoogle Scholar
  • 18 Lejeune J-P, Le Gars D, Haddad E. Tumors of the third ventricle: review of 262 cases. [in French]. Neurochirurgie 2000; 46 (3) 211-238
    PubMedGoogle Scholar
  • 19 Villani RM, Tomei G. Transcallosal approach to tumours of the third ventricle. In: Sweet SA, , ed. Operative Neurosurgical Techniques, Indications, Methods, and Results. Vol. 1, 4th ed. Philadelphia, PA: WB Saunders; 2000: 862-875
    Google Scholar
  • 20 Prieto R, Pascual JM, Roda JM. Third ventricle glioblastoma. Case report and review of literature. Clin Neurol Neurosurg 2006; 108 (2) 199-204
    CrossrefPubMedGoogle Scholar
  • 21 Ahmadloo N, Kani AA, Mohammadianpanah M , et al. Treatment outcome and prognostic factors of adult glioblastoma multiforme. J Egypt Natl Canc Inst 2013; 25 (1) 21-30
    PubMedGoogle Scholar
  • 22 Galli R, Binda E, Orfanelli U , et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 2004; 64 (19) 7011-7021
    CrossrefPubMedGoogle Scholar
  • 23 Matsuyama N, Uwano T, Hori E, Ono T, Nishijo H. Reward contingency modulates neuronal activity in rat septal nuclei during elemental and configural association tasks. Front Behav Neurosci 2011; 5: 26
    PubMedGoogle Scholar
  • 24 Sarnat HB, Netsky MG. Evolution of the Nervous System. New York, NY: Oxford University Press; 1974
    Google Scholar
  • 25 Steffenhagen C, Dechant FX, Oberbauer E , et al. Mesenchymal stem cells prime proliferating adult neural progenitors toward an oligodendrocyte fate. Stem Cells Dev 2012; 21 (11) 1838-1851
    CrossrefPubMedGoogle Scholar