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Synlett 2016; 27(01): 25-28
DOI: 10.1055/s-0035-1560592
DOI: 10.1055/s-0035-1560592
letter
Silver-Mediated 18F-Labeling of Aryl-CF3 and Aryl-CHF2 with 18F-Fluoride
Further Information
Publication History
Received: 16 October 2015
Accepted after revision: 03 November 2015
Publication Date:
20 November 2015 (online)
In celebration of Prof. Steven Ley’s 70th birthday
Abstract
We report the synthesis of [18F]arylCF3 and [18F]arylCHF2 derivatives from arylCF2Br and arylCHFCl precursors applying a silver-mediated halogen exchange with [18F]fluoride. In the absence of Ag(I)OTf, no reaction takes place at room temperature for both classes of substrates; this result demonstrates the beneficial role of silver(I) as a means to induce 18F-incorporation under very mild conditions.
Key words
radiochemistry - halogen exchange - silver - fluoride - trifluoromethylarenes - difluoromethylarenesSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560592.
- Supporting Information
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References and Notes
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