Synlett 2016; 27(10): 1450-1455
DOI: 10.1055/s-0035-1561416
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© Georg Thieme Verlag Stuttgart · New York

A Massé Shot: Transition-Metal-Catalyzed Selective meta-C–H Functionalization (ortho-Metallation and para-Bromination Relay)

Liu Liu
a  School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, P. R. of China
,
Qing Wang
a  School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, P. R. of China
,
Ranran Zhu
a  School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, P. R. of China
b  Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. of China
c  Tianjin Key Laboratory for Modern Drug Delivery & High Efficiency, Tianjin 300072, P. R. of China   Email: jhuang@tju.edu.cn
,
Jianhui Huang*
a  School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, P. R. of China
b  Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. of China
c  Tianjin Key Laboratory for Modern Drug Delivery & High Efficiency, Tianjin 300072, P. R. of China   Email: jhuang@tju.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 31 December 2015

Accepted after revision: 22 February 2016

Publication Date:
17 March 2016 (online)

Abstract

Reviewed herein are a number of modern approaches for the meta-selective direct C–H functionalization of substituted arenes, including a recent discovery on Ru-catalyzed meta-bromination is also discussed with the mechanistically interesting features (ortho-metallation and para-functionalization relay).

1 Introduction

2 Transition-Metal-Mediated meta-C–H Activation

3 Ruthenium-Catalyzed meta-C–H Bromination

4 Conclusion and Future Directions

 
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