Synlett 2016; 27(12): 1753-1759
DOI: 10.1055/s-0035-1562144
synpacts
© Georg Thieme Verlag Stuttgart · New York

Chemical Innovation through Ligand Total Synthesis

Abraham Mendoza*
a  Department of Organic Chemistry and Berzelii EXSELENT Center for Porous Materials, Stockholm University, Arrhenius Laboratory, 106 91 Stockholm, Sweden   Email: abraham.mendoza@su.se
,
Kilian Colas
a  Department of Organic Chemistry and Berzelii EXSELENT Center for Porous Materials, Stockholm University, Arrhenius Laboratory, 106 91 Stockholm, Sweden   Email: abraham.mendoza@su.se
,
Samuel Suárez-Pantiga
a  Department of Organic Chemistry and Berzelii EXSELENT Center for Porous Materials, Stockholm University, Arrhenius Laboratory, 106 91 Stockholm, Sweden   Email: abraham.mendoza@su.se
,
Daniel C. G. Götz
b  Chemical Development, Bayer Pharma AG, Friedrich-Ebert-Str. 217-333, 42117 Wuppertal, Germany
,
Magnus J. Johansson
c  Innovative Medicines, Cardiovascular and Metabolic Diseases, Medicinal Chemistry, AstraZeneca R&D, Pepparedsleden 1, 431 83 Mölndal, Sweden
› Author Affiliations
Further Information

Publication History

Received: 15 March 2016

Accepted after revision: 08 April 2016

Publication Date:
18 May 2016 (online)

Dedicated to Prof. Shū Kobayashi

Abstract

Natural products are an abundant source of synthetic challenges that foster crucial breakthroughs in organic chemistry. Despite the superior complexity of these targets, ligand total synthesis can inspire solutions to unsolved chemical problems and provide access to creative catalyst designs. This Synpacts article presents a comparative analysis of natural and ligand total synthesis to provide a context for our recent research and motivate the importance of future undertakings in this area.

1 Introduction

2 Ligands as Artificial Total Synthesis Targets

3 Natural Product Total Synthesis: The Inspiration of Relevant New Methods

4 Selected Syntheses of Important Ligands

5 Total Synthesis of the Ligand PiPy6: The Invention of a New Organometallic Photoreaction

6 Conclusion

 
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