Synlett 2016; 27(16): 2285-2292
DOI: 10.1055/s-0035-1562505
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© Georg Thieme Verlag Stuttgart · New York

Progress towards the Synthesis of Amino Polyesters via Ring-Opening Polymerization (ROP) of Functional Lactones

Jing Haoa, Sussana Elkassihb, Daniel J. Siegwart*b
  • aDepartment of Chemistry, George Fox University, Newberg, OR 97132, USA
  • bSimmons Comprehensive Cancer Center, Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA   Email: daniel.siegwart@utsouthwestern.edu
Further Information

Publication History

Received: 15 April 2016

Accepted after revision: 30 May 2016

Publication Date:
07 July 2016 (eFirst)

Abstract

Amine-functionalized polyesters are an important class of materials for biomedical applications due to their utility in gene and drug delivery, bioconjugation reactions, hydrogels, and controlled release systems. The synthesis of amino polyesters by ring-opening polymerization (ROP) is an ongoing challenge that is being aided by advances in reaction development. For the benefit of this important research area, this article highlights the related works of synthesizing amino polyesters by ROP as well as our recent synthesis of a new library of amino polyesters from amine-functionalized lactone monomers.

1 Polymerization of Lactone Monomers with Unprotected Amine Functionalities

2 Synthesis of Amino-Functionalized Polyesters via Postpolymerization Modification of Functionalized Monomers

3 Design of Novel Amino-Functionalized Lactone Monomers and Direct Synthesis of Amino Polyesters