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Am J Perinatol 2016; 33(07): 703-707
DOI: 10.1055/s-0036-1571321
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Preeclampsia and Future Risk for Maternal Ophthalmic Complications

Ofer Beharier
1   Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel
,
Ehud Davidson
2   Faculty of Health Sciences, Soroka University Medical Center, Clalit Health Services (Southern District), Ben-Gurion University of the Negev, Beer-Sheva, Israel
,
Ruslan Sergienko
3   Public Health, Ben-Gurion University of the Negev, Beer-Sheva, Israel
,
Irit Szaingurten-Solodkin
4   Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
,
Roy Kessous
1   Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel
,
Ron Charach
1   Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel
,
Nadav J. Belfair
5   Department of Ophthalmology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel
,
Eyal Sheiner
1   Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel
› Author Affiliations
Further Information

Publication History

06 August 2015

03 December 2015

Publication Date:
12 February 2016 (online)

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Abstract

Objective To investigate whether patients with a history of preeclampsia have an increased risk of long-term ophthalmic complications.

Study Design A population-based study comparing the incidence of long-term maternal ophthalmic complications in a cohort of women with and without a history of preeclampsia.

Results During the study period, a total of 103,183 deliveries met the inclusion criteria; 8.1% (n = 8,324) occurred in patients with a diagnosis of preeclampsia during at least one of their pregnancies. Patients with preeclampsia had a significantly higher incidence of long-term ophthalmic morbidity such as diabetic retinopathy and retinal detachment. In addition, a positive linear correlation was found between the severity of preeclampsia and the prevalence of future ophthalmic morbidities (0.3 vs. 0.5 vs. 2.2%, respectively). Kaplan–Meier survival curve indicated that women with preeclampsia had higher rates of total ophthalmic morbidity (0.2 vs. 0.4%, for no preeclampsia and with preeclampsia, respectively; odds ratio = 2.06, 95% confidence interval: 1.42–2.99; p < 0.001). In a Cox proportional hazards model, adjusted for confounders, a history of preeclampsia remained independently associated with ophthalmic complications.

Conclusion Preeclampsia is an independent risk factor for long-term maternal ophthalmic morbidity, specifically diabetic retinopathy and retinal detachment. This risk is more substantial depending on the severity of the disease.

Keywords

long-term maternal morbidity - ophthalmic morbidities - preeclampsia

Note

The authors are responsible for study design; collection, analysis, and interpretation of data; writing of the report; and the decision to submit the report for publication.


This study was presented at the 35th Annual Meeting of the Society for Maternal-Fetal Medicine, February 2–7, 2015, San Diego, CA; Accepted for poster presentation.


Supplementary Material

 

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