1H NMR Metabonomic Approach Reveals Different Changes between Acupuncture And Moxibustion On Healthy Adults

To explore the difference mechanism of acupuncture and moxibustion on healthy young volunteers based on 1 H NMR. 90 healthy young volunteers randomly divided into moxibustion group, acupuncture group and blank group. In the end of the observation, there were 18 volunteers left in moxibustion group and 19 volunteers in acupuncture group and 21 volunteers in blank group. Each group choose the right “Zusanli” acupoint excepted blank group, while moxibustion group utilize igniting moxa roll to treat the acupoint, and acupuncture group utilize needle to treat the acupoint once a day. Collect the serum of each group on 0 day, 5 day and 10 day, and detect the metabolites changing by 1 H NMR. Compared with the blank group, the metabolic pattern of moxibustion and acupuncture group were changed significant; Through the metabolite sets enrichment overview we found the common pathway of moxibustion and acupuncture were protein biosynthesis, ammonia recycling. So, moxibustion and acupuncture have different biological effects on healthy young people, which performance in the metabolic pattern and metabolites, compared to acupuncture we considered an significant time-effect relationship in moxibustion effects on valine, leucine, isoleucinecan, which indicate moxibustion have a shorter time in reaching biological effects than acupuncture [1].

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Acknowledgements: Thanks go to graduate students Xiaomin Hu, Chang She, Jinping Gu, Anlin Guo, Houlian Wang, Junyun Ge, He Huang, Zhao for carrying out the trail and data analysis. Most support for this research from the National Basic Research Program of China (973 Program) (No. 2015CB554502) is gratefully acknowledged.

References: [1] G. Yan et al. (2013) EVID-BASED COMPL ALT, 2013: 429703 – 429703.