Global Spine J 2016; 06(08): 798-803
DOI: 10.1055/s-0036-1579746
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Systematic Review and Meta-analysis of En Bloc Vertebrectomy Compared with Intralesional Resection for Giant Cell Tumors of the Mobile Spine

Panya Luksanapruksa
Department of Orthopedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Jacob M. Buchowski
Department of Orthopedic Surgery, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States
Weerasak Singhatanadgige
Department of Orthopedic Surgery, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand
David B. Bumpass
Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, Arizona, United States
› Author Affiliations
Further Information

Publication History

24 September 2015

15 January 2016

Publication Date:
07 March 2016 (eFirst)


Study Design Systematic review and meta-analysis.

Objective To compare the recurrence and perioperative complication rate of en bloc vertebrectomy (EV) and intralesional resection (IR) in the giant cell tumor of the mobile spine (SGCT).

Methods We systematically searched publications in the PubMed and Embase databases for reports of SGCTs, excluding the sacrum. Two reviewers independently assessed all publications. A meta-analysis was performed using local recurrence and postoperative complications as the primary outcomes of interest.

Results There were four articles reporting recurrence and two articles reporting postoperative complications. All included articles were case series. In all, 91 patients were included; 49 were treated with IR and 42 were treated with EV. Local recurrence rates were 36.7 and 9.5% in the IR and EV groups, respectively. Rates of postoperative complications were 36.4% with IR and 11.1% with EV. Overall, patients treated with EV not only had a lower recurrence rate (relative risk [RR] 0.22; 95% confidence interval [CI] 0.09 to 0.52) but also had a lower postoperative complication rate (RR 0.34; 95% CI 0.07 to 1.52) compared with IR.

Conclusions Based on the limited data obtained from systematic review, SGCT patients treated with EV had a lower recurrence rate and fewer postoperative complications than those treated with IR.