Diabetologie und Stoffwechsel 2016; 11 - P226
DOI: 10.1055/s-0036-1580973

The effect of Morus alba leaves extract and powder on resistin and liver enzymes alteration in diabetic rats

Z Salemi 1, S Barzin Tond 1, S Fallah 2, A Shojaii 2
  • 1Arak University of Medical Sciences, Arak, Iran, Islamic Republic of
  • 2Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of

Aims: The current study was designed to explore the changes of the resistin, ALT and AST levels of diabetic rats after treatment with Morus alba leaves flavonoid extract (MLE) and Morus alba leaves powder (MLP).

Methods: The study was conducted for 30 male wistar rats in five groups including control and diabetic groups. Diabetic groups consisted of diabetic control, sham and treated group with MLE and MLP. Type 2 diabetes was induced in rats by administration of streptozotocin and nicotinamide. The serum concentrations of resistin and insulin in study groups were identified by ELISA. ALT and AST activities were assayed by spectrophotometer.

Results: It was shown that the uptake of MLE and MLP by diabetic rats could significantly decrease the serum FBG, resistin and enzymes activity of ALT and AST and increases the concentration of serum insulin significantly (P < 0.05) in comparison with the sham group and diabetic control. For all the investigated factors, there was no significant difference between two treatment methods.

Conclusions: In this study, the possible protective effect of MLE and MLP administration was evaluated against destructive effect of STZ on liver and pancreas function of diabetic rats. It was also shown that these effects play an important role in regulating the secretion of Adipokines such as resistin, which are involved in the control of diabetes and obesity. Our results suggest that MLE and MLP treatments could be useful agents in combination with other therapies in diabetes improvement.

Keywords: Morus alba, Type2 diabetes rat, Resistin.