Surfactant Treatment Threshold during NCPAP for the Treatment of Preterm Infants with Respiratory Distress Syndrome

Carlo Dani

doi:10.1055/s-0036-1582395

American Journal of Perinatology, Table of Contents

Am J Perinatol 2016; 33(10): 925-929
DOI: 10.1055/s-0036-1582395

Review Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Surfactant Treatment Threshold during NCPAP for the Treatment of Preterm Infants with Respiratory Distress Syndrome

Authors

Carlo Dani

¹Department of Neurosciences, Psychology, Drug Research and Child Health, Careggi University Hospital of Florence, Firenze, Italy

Abstract

Although surfactant is the most studied drug in the preterm infant, the best criteria for treatment of preterm infants with respiratory distress syndrome (RDS) with surfactant have been not extensively investigated. We assessed the criteria used for deciding the rescue surfactant treatment of preterm infants with RDS in combination with nasal continuous positive airway pressure as reported by the main recent randomized controlled trials. We evaluated 10 studies and found that the criteria chosen for administering selective surfactant were very heterogeneous, different types and doses of surfactant were used, and this limits their applicability in the clinical practice. In conclusion, although current data seem to suggest that low threshold is better than high threshold, additional studies are necessary to identify the most effective criteria for selective surfactant treatment of preterm infants with RDS.

Keywords

INSURE - failure - surfactant - NCPAP - preterm infant - threshold - respiratory distress syndrome

Full Text

References

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